Publications
2023
Nagai M, Moriyama M, Ishii C, Mori H, Watanabe H, Nakahara T, Yamada T, Ishikawa D, Ishikawa T, Hirayama A, Kimura I, Nagahara A, Naito T, Fukuda S, Ichinohe T. High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection. Nat Commun. 14(1):3863. https://doi.org/10.1038/s41467-023-39569-0 (2023)
論文解説 発熱がウイルス性肺炎の重症化を抑制するメカニズムを解明 ――重症化の抑制には38℃以上の体温で活性化した腸内細菌叢が必要だった――
Saito Y, Takahashi T, Hiramatsu K, Serada S, Fujimoto M, Ohkawara T, Sugase T, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Nakajima K, Yamasaki M, Ishii KJ, Eguchi H, Doki Y, Naka T. Nano-particulate Toll-like Receptor 9 Agonist Potentiates the Antitumor Activity of Anti-Glypican-1 Antibody. Anticancer Res. 43(6):2425-2432. https://doi.org/10.21873/anticanres.16410 (2023)
Tatsuma T, Nakakido M, Ichinohe T, Kuroiwa Y, Tomioka K, Liu C, Miyamae N, Onuki T, Tsumoto K, Hashimoto K, Wakihara T. Inactivation and spike protein denaturation of novel coronavirus variants by CuxO/TiO2 nano-photocatalysts. Sci Rep. 13(1) https://doi.org/10.1038/s41598-023-30690-0 (2023)
Kiso M, Furusawa Y, Uraki R, Imai M, Yamayoshi S, Kawaoka Y. In vitro and in vivo characterization of SARS-CoV-2 strains resistant to nirmatrelvir. Nat Commun. 14(1):3952-x. https://doi.org/10.1038/s41467-023-39704-x (2023)
Halfmann PJ, Uraki R, Kuroda M, Iwatsuki-Horimoto K, Yamayoshi S, Ito M, Kawaoka Y. Transmission and re-infection of Omicron variant XBB.1.5 in hamsters. eBioMedicine. 93:104677. https://doi.org/10.1016/j.ebiom.2023.104677 (2023)
論文解説 新型コロナウイルス・オミクロン株XBB.1.5系統は、 ハムスターで初期のオミクロン系統よりも伝播しやすい
Yamasoba D, Uriu K, Plianchaisuk A, Kosugi Y, Pan L, Zahradnik J, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ito J, Sato K. Virological characteristics of the SARS-CoV-2 omicron XBB.1.16 variant. Lancet Infect Dis. 23(6):655-656. https://doi.org/10.1016/S1473-3099(23)00278-5 (2023)
論文解説 SARS-CoV-2オミクロンXBB.1.16株の ウイルス学的特性の解明
Yamada S, Nagafuchi Y, Wang M, Ota M, Hatano H, Takeshima Y, Okubo M, Kobayashi S, Sugimori Y, Masahiro N, Yoshida R, Hanata N, Suwa Y, Tsuchida Y, Iwasaki Y, Sumitomo S, Kubo K, Shimane K, Setoguchi K, Azuma T, Kanda H, Shoda H, Zhang X, Yamamoto K, Ishigaki K, Okamura T, Fujio K. Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance. Ann Rheum Dis. 82(6):809-819. https://doi.org/10.1136/ard-2022-223645 (2023)
Tamura D, Kawaoka Y. Omicron proliferation in the nasal cavity may explain its high infectivity. J Infect. 86(6):584-587. https://doi.org/10.1016/j.jinf.2023.03.006 (2023)
Fujikawa D, Nakamura T, Yoshioka D, Li Z, Moriizumi H, Taguchi M, Tokai-Nishizumi N, Kozuka-Hata H, Oyama M, Takekawa M. Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases. Curr Biol. 33(10):1967-1981.e8. https://doi.org/10.1016/j.cub.2023.04.012 (2023)
論文解説 液-液相分離体「ストレス顆粒」形成による ストレス防御および癌進展機構の解明 ――ストレス環境下で細胞がアポトーシスを回避する新たな仕組みを発見――
Nakamura Y, Moi ML, Shiina T, Shin-I T, Suzuki R. Idiotope-Driven T-Cell/B-Cell Collaboration-Based T-Cell Epitope Prediction Using B-Cell Receptor Repertoire Sequences in Infectious Diseases. Viruses-Basel. 15(5):1186. https://doi.org/10.3390/v15051186 (2023)
Nagao A, Nakanishi Y, Yamaguchi Y, Mishina Y, Karoji M, Toya T, Fujita T, Iwasaki S, Miyauchi K, Sakaguchi Y, Suzuki T. Quality control of protein synthesis in the early elongation stage. Nat Commun. 14(1):2704-5. https://doi.org/10.1038/s41467-023-38077-5 (2023)
Tamura T, Ito J, Uriu K, Zahradnik J, Kida I, Anraku Y, Nasser H, Shofa M, Oda Y, Lytras S, Nao N, Itakura Y, Deguchi S, Suzuki R, Wang L, Begum MM, Kita S, Yajima H, Sasaki J, Sasaki-Tabata K, Shimizu R, Tsuda M, Kosugi Y, Fujita S, Pan L, Sauter D, Yoshimatsu K, Suzuki S, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Schreiber G, Maenaka K, Genotype to Phenotype Japan (G2P-Japan) Consortium, Hashiguchi T, Ikeda T, Fukuhara T, Saito A, Tanaka S, Matsuno K, Takayama K, Sato K. Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants. Nat Commun. 14(1):2800-3. https://doi.org/10.1038/s41467-023-38435-3 (2023)
論文解説 オミクロンXBB株の進化経路とウイルス学的特性の解明 ――遺伝子組換えによる更なる免疫逃避能力の獲得――
Ikeuchi K, Ivic N, Buschauer R, Cheng J, Froehlich T, Matsuo Y, Berninghausen O, Inada T, Becker T, Beckmann R. Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. Nat Commun. 14(1):2730. https://doi.org/10.1038/s41467-023-38161-w (2023)
Ito J, Suzuki R, Uriu K, Itakura Y, Zahradnik J, Kimura KT, Deguchi S, Wang L, Lytras S, Tamura T, Kida I, Nasser H, Shofa M, Begum MM, Tsuda M, Oda Y, Suzuki T, Sasaki J, Sasaki-Tabata K, Fujita S, Yoshimatsu K, Ito H, Nao N, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Kuramochi J, Schreiber G, Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito A, Matsuno K, Takayama K, Hashiguchi T, Tanaka S, Fukuhara T, Ikeda T, Sato K. Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant. Nat Commun. 14(1):2671-z. https://doi.org/10.1038/s41467-023-38188-z (2023)
論文解説 SARS-CoV-2オミクロン株の進化パターンの一端を解明 ――スパイクタンパク質の収斂進化が適応度の高い変異株の出現に繋がる――
Uraki R, Ito M, Kiso M, Yamayoshi S, Iwatsuki-Horimoto K, Sakai-Tagawa Y, Imai M, Koga M, Yamamoto S, Adachi E, Saito M, Tsutsumi T, Otani A, Kashima Y, Kikuchi T, Theiler J, Yotsuyanagi H, Suzuki Y, Korber B, Kawaoka Y. Efficacy of antivirals and mRNA vaccination against an XBF clinical isolate. Lancet Reg Health West Pac. 34:100777. https://doi.org/10.1016/j.lanwpc.2023.100777 (2023)
論文解説 BA.4/5株対応2価mRNAワクチン接種で、 新型コロナウイルス・オミクロン株XBF系統に対する 中和活性は増強される
Uraki R, Ito M, Kiso M, Yamayoshi S, Iwatsuki-Horimoto K, Sakai-Tagawa Y, Furusawa Y, Imai M, Koga M, Yamamoto S, Adachi E, Saito M, Tsutsumi T, Otani A, Kashima Y, Kikuchi T, Yotsuyanagi H, Suzuki Y, Kawaoka Y. Efficacy of antivirals and bivalent mRNA vaccines against SARS-CoV-2 isolate CH.1.1. Lancet Infect Dis. 23(5):525-526. https://doi.org/10.1016/S1473-3099(23)00132-9 (2023)
論文解説 新型コロナウイルス・オミクロン株のCH.1.1系統に対する 治療薬と2価ワクチンの効果を検証
Amada K, Hijiya N, Ikarimoto S, Yanagihara K, Hanada T, Hidano S, Kurogi S, Tsukamoto Y, Nakada C, Kinoshita K, Hirashita Y, Uchida T, Shin T, Yada K, Hirashita T, Kobayashi T, Murakami K, Inomata M, Shirao K, Aoki M, Takekawa M, Moriyama M. Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor. Cancer Sci. 114(5):2189-2202. https://doi.org/10.1111/cas.15735 (2023)
Furusawa Y, Kiso M, Iida S, Uraki R, Hirata Y, Imai M, Suzuki T, Yamayoshi S, Kawaoka Y. In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamsters. EBioMedicine. 91:104561. https://doi.org/10.1016/j.ebiom.2023.104561 (2023)
論文解説 新型コロナウイルス・デルタ変異株の Spike-P681RおよびD950N変異の機能解析
Guan L, Zhong G, Fan S, Plisch EM, Presler R, Gu C, Babujee L, Pattinson D, Le Khanh Nguyen H, Hoang VMP, Le MQ, van Bakel H, Neumann G, Kawaoka Y. Highly Pathogenic H5 Influenza Viruses Isolated between 2016 and 2017 in Vietnamese Live Bird Markets. Viruses-Basel. 15(5):1093. https://doi.org/10.3390/v15051093 (2023)
Ekemen S, Comunoglu C, Kayhan CK, Bilir E, Cavusoglu I, Etiler N, Bilgi S, Ince U, Coban C, Erden HF. Endometrial Staining of CD56 (Uterine Natural Killer), BCL-6, and CD138 (Plasma Cells) Improve Diagnosis and Clinical Pregnancy Outcomes in Unexplained Infertility and Recurrent IVF Failures: Standardization of Diagnosis with Digital Pathology. Diagnostics. 13(9):1557. https://doi.org/10.3390/diagnostics13091557 (2023)
Muramoto Y, Takahashi S, Halfmann PJ, Gotoh S, Noda T, Kawaoka Y. Replicative capacity of SARS-CoV-2 omicron variants BA.5 and BQ.1.1 at elevated temperatures. Lancet Microbe. https://doi.org/10.1016/S2666-5247(23)00100-3 (2023)
論文解説 新型コロナウイルス・オミクロン株のBA.5系統およびBQ.1.1系統が、高温で増殖しづらいことを解明
Nakagawa R, Hirano H, Omura SN, Nety S, Kannan S, Altae-Tran H, Yao X, Sakaguchi Y, Ohira T, Wu WY, Nakayama H, Shuto Y, Tanaka T, Sano FK, Kusakizako T, Kise Y, Itoh Y, Dohmae N, van der Oost J, Suzuki T, Zhang F, Nureki O. Cryo-EM structure of the transposon-associated TnpB enzyme. Nature. https://doi.org/10.1038/s41586-023-05933-9 (2023)
Uraki R, Ito M, Kiso M, Yamayoshi S, Iwatsuki-Horimoto K, Furusawa Y, Sakai-Tagawa Y, Imai M, Koga M, Yamamoto S, Adachi E, Saito M, Tsutsumi T, Otani A, Kikuchi T, Yotsuyanagi H, Halfmann PJ, Pekosz A, Kawaoka Y. Antiviral and bivalent vaccine efficacy against an omicron XBB.1.5 isolate. Lancet Infect Dis. 23(4):402-403. https://doi.org/10.1016/S1473-3099(23)00070-1 (2023)
論文解説 新型コロナウイルス・オミクロン株のXBB.1.5系統に対する 治療薬とワクチンの効果を検証
Moriizumi H, Kubota Y, Tsuchiya T, Naka R, Takekawa M. Caspase 3-specific cleavage of MEK1 suppresses ERK signaling and sensitizes cells to stress-induced apoptosis. FEBS Open Bio. 13(4):684-700. https://doi.org/10.1002/2211-5463.13574 (2023)
Sun X, Hosomi K, Shimoyama A, Yoshii K, Lan H, Wang Y, Yamaura H, Nagatake T, Ishii KJ, Akira S, Kiyono H, Fukase K, Kunisawa J. TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells. Int Immunopharmacol. 117:109852. https://doi.org/10.1016/j.intimp.2023.109852 (2023)
Ito D, Ito H, Ando T, Sakai Y, Ideta T, Ishii KJ, Ishikawa T, Shimizu M. Spermidine enhances the efficacy of adjuvant in HBV vaccination in mice. Hepatol Commun. 7(4):e0104. doi: 10.1097/HC9.0000000000000104. eCollection 2023 Apr 1. https://doi.org/10.1097/HC9.0000000000000104 (2023)
Uraki R, Iida S, Halfmann PJ, Yamayoshi S, Hirata Y, Iwatsuki-Horimoto K, Kiso M, Ito M, Furusawa Y, Ueki H, Sakai-Tagawa Y, Kuroda M, Maemura T, Kim T, Mine S, Iwamoto N, Li R, Liu Y, Larson D, Fukushi S, Watanabe S, Maeda K, Wang Z, Ohmagari N, Theiler J, Fischer W, Korber B, Imai M, Suzuki T, Kawaoka Y. Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates. Nat Commun. 14(1):1620-x. https://doi.org/10.1038/s41467-023-37059-x (2023)
論文解説 新型コロナウイルス・オミクロン変異株のBA.2.75系統の性状解析
Tomoda E, Nagao A, Shirai Y, Asano K, Suzuki T, Battersby BJ, Suzuki T. Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases. Nucleic Acids Res. https://doi.org/10.1093/nar/gkad139 (2023)
Okamoto K, Takayanagi H. Effect of T cells on bone. Bone. 168:116675. https://doi.org/10.1016/j.bone.2023.116675 (2023)
Uriu K, Ito J, Zahradnik J, Fujita S, Kosugi Y, Schreiber G, Sato K. Enhanced transmissibility, infectivity, and immune resistance of the SARS-CoV-2 omicron XBB.1.5 variant. Lancet Infect Dis. 23(3):280-281. https://doi.org/10.1016/S1473-3099(23)00051-8 (2023)
論文解説 SARS-CoV-2オミクロンXBB.1.5株のウイルス学的性状の解明
Fukui A, Maruzuru Y, Takeshima K, Koyanagi N, Kato A, Kawaguchi Y. Establishment of a system to quantify wild-type herpes simplex virus-induced cell-cell fusion reveals a role of N-glycosylation of HSV-1 envelope glycoprotein B in cell-cell fusion. Microbiol Immunol. 67(3):114-119. https://doi.org/10.1111/1348-0421.13050 (2023)
Wijaya TJ, Yokota T, Lee S, Okano R, Kobayashi M, Someya T. Photostability Improvement of Organic Photodiodes with ZnO Electron Transport Layer. Adv Photon Res. 4(3) https://doi.org/10.1002/adpr.202200355 (2023)
Furusawa Y, Yamayoshi S, Kawaoka Y. The accuracy of reverse genetics systems for SARS-CoV-2: Circular polymerase extension reaction versus bacterial artificial chromosome. Influenza Other Respir Viruses. 17(3):e13109. https://doi.org/10.1111/irv.13109 (2023)
Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori S, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H. Identification of SARS-CoV-2 M(pro) inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nat Commun. 14(1):1076-0. https://doi.org/10.1038/s41467-023-36729-0 (2023)
Yotsuyanagi H, Ohmagari N, Doi Y, Imamura T, Sonoyama T, Ichihashi G, Sanaki T, Tsuge Y, Uehara T, Mukae H. A phase 2/3 study of S-217622 in participants with SARS-CoV-2 infection (Phase 3 part). Medicine (Baltimore). 102(8):e33024. https://doi.org/10.1097/MD.0000000000033024 (2023)
Iwatsuki-Horimoto K, Ueki H, Ito M, Nagasawa S, Hirata Y, Hashizume K, Ushiwata K, Iwase H, Makino Y, Ushiku T, Akitomi S, Imai M, Saitoh H, Kawaoka Y. SARS-CoV-2 Transmission from Virus-Infected Dead Hamsters. mSphere. 8(1) https://doi.org/10.1128/msphere.00411-22 (2023)
論文解説 SARS-CoV-2感染動物死体からのウイルス伝播
Yoshioka Y, Kobiyama K, Hayashi T, Onishi M, Yanagida Y, Nakagawa T, Hashimoto M, Nishinaka A, Hirose J, Asaoka Y, Tajiri M, Hayata A, Ishida S, Omoto S, Nagira M, Ishii KJ. A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via alpha-tocopherol component. Front Immunol. 14:1116238. https://doi.org/10.3389/fimmu.2023.1116238 (2023)
Best K, Ikeuchi K, Kater L, Best D, Musial J, Matsuo Y, Berninghausen O, Becker T, Inada T, Beckmann R. Structural basis for clearing of ribosome collisions by the RQT complex. Nat Commun. 14(1):921-8. https://doi.org/10.1038/s41467-023-36230-8 (2023)
論文解説 異常翻訳の実体である衝突リボソームの解消機構 ――mRNA引っ張り力によるリボソーム構造変化による異常翻訳解消機構――
Tesina P, Ebine S, Buschauer R, Thoms M, Matsuo Y, Inada T, Beckmann R. Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol Cell. 83(4):607-621.e4. https://doi.org/10.1016/j.molcel.2023.01.020 (2023)
論文解説 非典型翻訳反応における翻訳因子eIF5Aの機能の解明 ――mRNAを必要とせずにペプチド合成反応を行う仕組み――
Soga T, Duong C, Pattinson D, Sakai-Tagawa Y, Tokita A, Izumida N, Nishino T, Hagiwara H, Wada N, Miyamoto Y, Kuroki H, Hayashi Y, Seki M, Kasuya N, Koga M, Adachi E, Iwatsuki-Horimoto K, Yotsuyanagi H, Yamayoshi S, Kawaoka Y. Characterization of Influenza A(H1N1)pdm09 Viruses Isolated in the 2018-2019 and 2019-2020 Influenza Seasons in Japan. Viruses. 15(2):535. https://doi.org/10.3390/v15020535 (2023)
Miyashita R, Nishiyama A, Qin W, Chiba Y, Kori S, Kato N, Konishi C, Kumamoto S, Kozuka-Hata H, Oyama M, Kawasoe Y, Tsurimoto T, Takahashi TS, Leonhardt H, Arita K, Nakanishi M. The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Elife. 12:10.7554/eLife.79013. https://doi.org/10.7554/eLife.79013 (2023)
Sugimori Y, Iwasaki Y, Takeshima Y, Okubo M, Kobayashi S, Hatano H, Yamada S, Nakano M, Yoshida R, Ota M, Tsuchida Y, Nagafuchi Y, Shimane K, Yoshida K, Kurosaka D, Sumitomo S, Shoda H, Yamamoto K, Okamura T, Fujio K. Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of Myositis-Specific Antibody-Positive Inflammatory Myopathies. ACR Open Rheumatol. 5(2):93-102. https://doi.org/10.1002/acr2.11521 (2023)
Neumann G, Kawaoka Y. The COVID-19 Pandemic-A Potential Role for Antivirals in Mitigating Pandemics. Viruses. 15(2):303. https://doi.org/10.3390/v15020303 (2023)
Ly MHP, Nguyen CT, Nguyen TV, Nguyen TTN, Nabeshima T, Adungo F, Takamatsu Y, Huy NT, Le TQM, Morita K, Hasebe F, Moi ML. Differential Infectivity of Human Neural Cell Lines by a Dengue Virus Serotype-3 Genotype-III with a Distinct Nonstructural Protein 2A (NS2A) Amino Acid Substitution Isolated from the Cerebrospinal Fluid of a Dengue Encephalitis Patient. Can J Infect Dis Med Microbiol. 2023:2635383. https://doi.org/10.1155/2023/2635383 (2023)
Muro R, Narita T, Nitta T, Takayanagi H. Spleen tyrosine kinase mediates the gammadeltaTCR signaling required for gammadeltaT cell commitment and gammadeltaT17 differentiation. Front Immunol. 13:1045881. https://doi.org/10.3389/fimmu.2022.1045881 (2023)
Tomomatsu S, Watanabe A, Tesina P, Hashimoto S, Ikeuchi K, Li S, Matsuo Y, Beckmann R, Inada T. Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay. Nucleic Acids Res. 51(1):253-270. https://doi.org/10.1093/nar/gkac1172 (2023)
論文解説 リボソーム衝突に依存したmRNAの内部切断の仕組み
Neumann G, Kawaoka Y. Which Virus Will Cause the Next Pandemic? Viruses. 15(1):199. https://doi.org/10.3390/v15010199 (2023)
Matsuo Y, Uchihashi T, Inada T. Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex. Nat Commun. 14(1):79-4. https://doi.org/10.1038/s41467-022-35608-4 (2023)
論文解説 リボソームの異常な交通渋滞を選別するしくみを解明 ――高速AFMを用いて品質管理を司る複合体の動きを可視化――
Minagawa Y, Nakata S, Date M, Ii Y, Noji H. On-Chip Enrichment System for Digital Bioassay Based on Aqueous Two-Phase System. ACS Nano. 17(1):212-220. https://doi.org/10.1021/acsnano.2c06007 (2023)
Chiba S, Hatta M, Pattinson D, Yasuhara A, Neumann G, Kawaoka Y. Ferret model to mimic the sequential exposure of humans to historical H3N2 influenza viruses. Vaccine. 41(2) https://doi.org/10.1016/j.vaccine.2022.12.005 (2023)
Imai M, Ito M, Kiso M, Yamayoshi S, Uraki R, Fukushi S, Watanabe S, Suzuki T, Maeda K, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Halfmann PJ, Kawaoka Y. Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB. N Engl J Med. 388(1):89-91. https://doi.org/10.1056/NEJMc2214302 (2023)
論文解説 臨床検体から分離した新型コロナウイルス・オミクロン株の BQ.1.1系統とXBB系統に対する治療薬の効果を検証
Jin J, Ogawa T, Hojo N, Kryukov K, Shimizu K, Ikawa T, Imanishi T, Okazaki T, Shiroguchi K. Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes. Proc Natl Acad Sci U S A. 120(1):e2210283120. https://doi.org/10.1073/pnas.2210283120 (2023)
Takashita E, Watanabe S, Hasegawa H, Kawaoka Y. Are twindemics occurring? Influenza Other Respir Viruses. 17(1):e13090. https://doi.org/10.1111/irv.13090 (2023)
論文解説 新型コロナウイルス感染症とインフルエンザが同時流行しているかを検証
Bae C, Katoh H, Wakata A, Sakata M, Kato F, Takeda M. Demonstration of bacterium-free very rapid reverse genetics system using mumps virus. Microbiol Immunol. 67(1):44-47. https://doi.org/10.1111/1348-0421.13032 (2023)
Uraki R, Ito M, Furusawa Y, Yamayoshi S, Iwatsuki-Horimoto K, Adachi E, Saito M, Koga M, Tsutsumi T, Yamamoto S, Otani A, Kiso M, Sakai-Tagawa Y, Ueki H, Yotsuyanagi H, Imai M, Kawaoka Y. Humoral immune evasion of the omicron subvariants BQ.1.1 and XBB. Lancet Infect Dis. 23(1):30-32. https://doi.org/10.1016/S1473-3099(22)00816-7 (2023)
論文解説 ワクチン被接種者あるいはブレイクスルー感染者血漿の、 臨床検体から分離した新型コロナウイルス・オミクロン株の BQ.1.1系統とXBB系統に対する反応性を検証
Furuya G, Katoh H, Atsumi S, Hashimoto I, Komura D, Hatanaka R, Senga S, Hayashi S, Akita S, Matsumura H, Miura A, Mita H, Nakakido M, Nagatoishi S, Sugiyama A, Suzuki R, Konishi H, Yamamoto A, Abe H, Hiraoka N, Aoki K, Kato Y, Seto Y, Yoshimura C, Miyadera K, Tsumoto K, Ushiku T, Ishikawa S. Nucleic acid-triggered tumoral immunity propagates pH-selective therapeutic antibodies through tumor-driven epitope spreading. Cancer Sci. 114(1):321-338. https://doi.org/10.1111/cas.15596 (2023)
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Moritoyo T, Nishimura N, Hasegawa K, Ishii S, Kirihara K, Takata M, Svensson AK, Umeda-Kameyama Y, Kawarasaki S, Ihara R, Sakanaka C, Wakabayashi Y, Niizuma K, Tominaga T, Yamazaki T, Hasumi K. A first-in-human study of the anti-inflammatory profibrinolytic TMS-007, an SMTP family triprenyl phenol. Br J Clin Pharmacol. https://doi.org/10.1111/bcp.15651 (2023)
2022
Takeshima K, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y. Redundant and Specific Roles of A-Type Lamins and Lamin B Receptor in Herpes Simplex Virus 1 Infection. J Virol. 96(24):1429. https://doi.org/10.1128/jvi.01429-22 (2022)
Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada H, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat Commun. 13(1):7857-0. https://doi.org/10.1038/s41467-022-35501-0 (2022)
Uraki R, Halfmann PJ, Iida S, Yamayoshi S, Furusawa Y, Kiso M, Ito M, Iwatsuki-Horimoto K, Mine S, Kuroda M, Maemura T, Sakai-Tagawa Y, Ueki H, Li R, Liu Y, Larson D, Fukushi S, Watanabe S, Maeda K, Pekosz A, Kandeil A, Webby RJ, Wang Z, Imai M, Suzuki T, Kawaoka Y. Characterization of SARS-CoV-2 Omicron BA.4 and BA.5 isolates in rodents. Nature. 612(7940):540-+. https://doi.org/10.1038/s41586-022-05482-7 (2022)
論文解説 患者から分離した新型コロナウイルス・オミクロン変異株のBA.4系統ならびにBA.5系統の性状解明
Kawasaki T, Ikegawa M, Yunoki K, Otani H, Ori D, Ishii KJ, Kuroda E, Takamura S, Kitabatake M, Ito T, Isotani A, Kawai T. Alveolar macrophages instruct CD8(+) T cell expansion by antigen cross-presentation in lung. Cell Rep. 41(11):111828. https://doi.org/10.1016/j.celrep.2022.111828 (2022)
Ohe S, Kubota Y, Yamaguchi K, Takagi Y, Nashimoto J, Kozuka-Hata H, Oyama M, Furukawa Y, Takekawa M. ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II. Nat Commun. 13(1):7476-4. https://doi.org/10.1038/s41467-022-35230-4 (2022)
論文解説 細胞増殖と発癌を司る初期応答遺伝子群の新たな発現調節機構の解明 ―増殖シグナルがRNAポリメラーゼIIの転写伸長反応を制御する仕組みを発見―
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Otsubo R, Minamitani T, Kobiyama K, Fujita J, Ito T, Ueno S, Anzai I, Tanino H, Aoyama H, Matsuura Y, Namba K, Imadome K, Ishii KJ, Tsumoto K, Kamitani W, Yasui T. Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein. Sci Rep. 12(1):20120-4. https://doi.org/10.1038/s41598-022-24730-4 (2022)
Kikuchi A, Onoda H, Yamaguchi K, Kori S, Matsuzawa S, Chiba Y, Tanimoto S, Yoshimi S, Sato H, Yamagata A, Shirouzu M, Adachi N, Sharif J, Koseki H, Nishiyama A, Nakanishi M, Defossez P, Arita K. Structural basis for activation of DNMT1. Nat Commun. 13(1):7130-4. https://doi.org/10.1038/s41467-022-34779-4 (2022)
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論文解説 抗PD1抗体は老化細胞の免疫監視を強化し、老年病・生活習慣病を改善する
Hanata N, Ota M, Tsuchida Y, Nagafuchi Y, Okamura T, Shoda H, Fujio K. Serum extracellular traps associate with the activation of myeloid cells in SLE patients with the low level of anti-DNA antibodies. Sci Rep. 12(1):18397. https://doi.org/10.1038/s41598-022-23076-1 (2022)
Narita M, Denk T, Matsuo Y, Sugiyama T, Kikuguchi C, Ito S, Sato N, Suzuki T, Hashimoto S, Machova I, Tesina P, Beckmann R, Inada T. A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation. Nat Commun. 13(1):6411-9. https://doi.org/10.1038/s41467-022-34097-9 (2022)
論文解説 哺乳類においてリボソームの衝突に対処する仕組み ――ユビキチン修飾を介した翻訳停滞の解消を試験管内で再現――