研究

2025　 (Updated on 24 April 2025)

1. Koyanagi N, Hengphasatporn K, Kato A, Nobe M, Takeshima K, Maruzuru Y, Maenaka K, Shigeta Y, Kawaguchi Y. Regulatory mimicry of cyclin-dependent kinases by a conserved herpesvirus protein kinase. Proceedings of the National Academy of Sciences. 122(16):e2500264122. https://doi.org/10.1073/pnas.2500264122 (2025)

論文解説　ウイルスの生存戦略を司る分子模倣を解明 ―ウイルスキナーゼは宿主キナーゼの機能だけでなく、調節機構も模倣する―

2. Yamada Y, Sankoda N, Yamada Y. In Vivo Reprogramming Highlights Epigenetic Regulation That Shapes Cancer Hallmarks. Cancer Sci. https://doi.org/10.1111/cas.70067 (2025)

3. Kobiyama K, Utsumi D, Kaku Y, Sasaki E, Yasui F, Okamura T, Onodera T, Tobuse AJ, Sakkour A, Amiry AF, Hayashi T, Temizoz B, Liu K, Negishi H, Toyama-Sorimachi N, Kohara M, Sawasaki T, Takagi J, Sato K, Takahashi Y, Yasutomi Y, Ishii KJ. Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpox. eBioMedicine. 115:105703. https://doi.org/10.1016/j.ebiom.2025.105703 (2025)

論文解説　エムポックス（MPOX）に対する日本発ワクチンの免疫学―LC16m8ワクチン接種による免疫応答を初めて包括的に解析した研究成果を発表―

4. Yamamoto K, Nagatoishi S, Matsunaga R, Nakakido M, Kuroda D, Tsumoto K. Affinity-stability trade-off mechanism of residue 35 in framework region 2 of VHH antibodies with β-hairpin CDR3. Protein Sci. 34(4):e70095. https://doi.org/10.1002/pro.70095 (2025)

5. Iwatsuki-Horimoto K, Uraki R, Ito M, Wang T, Guan L, Halfmann P, Eisfeld A, Neumann G, Yamayoshi S, Kawaoka Y. Transmission of bovine H5N1 virus in a hamster model. J Virol. https://doi.org/10.1128/jvi.00147-25 (2025)

6. Koide S, Oshima M, Kamiya T, Zheng Z, Liu Z, Rizq O, Nishiyama A, Murakami K, Yamada Y, Nakajima-Takagi Y, Rahmutulla B, Kaneda A, Yokoyama K, Yusa N, Imoto S, Miura F, Ito T, Tamura T, Nerlov C, Yamashita M, Iwama A. Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the lifespan. Blood. https://doi.org/10.1182/blood.2024025776 (2025)

7. Weller C, Bartok O, McGinnis CS, Palashati H, Chang T, Malko D, Shmueli MD, Nagao A, Hayoun D, Murayama A, Sakaguchi Y, Poulis P, Khatib A, Erlanger Avigdor B, Gordon S, Cohen Shvefel S, Zemanek MJ, Nielsen MM, Boura-Halfon S, Sagie S, Gumpert N, Yang W, Alexeev D, Kyriakidou P, Yao W, Zerbib M, Greenberg P, Benedek G, Litchfield K, Petrovich-Kopitman E, Nagler A, Oren R, Ben-Dor S, Levin Y, Pilpel Y, Rodnina M, Cox J, Merbl Y, Satpathy AT, Carmi Y, Erhard F, Suzuki T, Buskirk AR, Olweus J, Ruppin E, Schlosser A, Samuels Y. Translation dysregulation in cancer as a source for targetable antigens. Cancer cell. https://doi.org/10.1016/j.ccell.2025.03.003 (2025) 

8. Izuka S, Komai T, Tsuchida Y, Tsuchiya H, Okamura T, Fujio K. The role of monocytes and macrophages in idiopathic inflammatory myopathies: insights into pathogenesis and potential targets. Frontiers in Immunology. 16:1567833. https://doi.org/10.3389/fimmu.2025.1567833 (2025)

9. Furusawa Y, Kiso M, Uraki R, Sakai-Tagawa Y, Nagai H, Koga M, Kashima Y, Hojo M, Iwamoto N, Iwatsuki-Horimoto K, Ohmagari N, Suzuki Y, Yotsuyanagi H, Halfmann PJ, Kamitani W, Yamayoshi S, Kawaoka Y. Amino acid substitutions in NSP6 and NSP13 of SARS-CoV-2 contribute to superior virus growth at low temperatures. J Virol. 99(3):e0221724–24. Epub 2025 Feb 12. https://doi.org/10.1128/jvi.02217-24 (2025)

10. Park H, Kingstad-Bakke B, Cleven T, Jung M, Kawaoka Y, Suresh M. Diversifying T-cell responses: safeguarding against pandemic influenza with mosaic nucleoprotein. J Virol. 99(3):e0086724–24. Epub 2025 Feb 3. https://doi.org/10.1128/jvi.00867-24 (2025)

11. Ukaji T, Arai D, Tsutsumi H, Nakagawa R, Matsumoto F, Ikeda K, Nureki O, Kamiya K. AAV-mediated base editing restores cochlear gap junction in GJB2 dominant-negative mutation-associated syndromic hearing loss model. JCI Insight. 10(5):e185193. doi: 10.1172/jci.insight.185193. https://doi.org/10.1172/jci.insight.185193 (2025)

12. Sato N, Nakano Y, Matsuki Y, Tomomatsu S, Li S, Matsuo Y, Inada T. Crucial roles of Grr1 in splicing and translation of HAC1 mRNA upon unfolded stress response. Nat Commun. 16(1):2172–1. https://doi.org/10.1038/s41467-025-57360-1 (2025)

13. Matsunaga R*, Tsumoto K. FASTIA: A rapid and accessible platform for protein variant interaction analysis demonstrated with a single-domain antibody. Protein Sci. 34(3):e70065. https://doi.org/10.1002/pro.70065 (2025)

14. Takashita E, Shimizu K, Kawakami C, Momoki T, Saikusa M, Ozawa H, Kumazaki M, Usuku S, Tanaka N, Senda R, Okubo I, Fujisaki S, Nagata S, Morita H, Miura H, Watanabe K, Nakauchi M, Matsuzaki Y, Watanabe S, Hasegawa H, Kawaoka Y. Impact of COVID-19 on Respiratory Virus Infections in Children, Japan, 2018-2023. Immun Inflamm Dis. 13(3):e70176. https://doi.org/10.1002/iid3.70176 (2025)

15. Yano S, Asami N, Kishi Y, Takeda I, Kubotani H, Hattori Y, Kitazawa A, Hayashi K, Kubo K, Saeki M, Maeda C, Hiraki C, Teruya R, Taketomi T, Akiyama K, Okajima-Takahashi T, Sato B, Wake H, Gotoh Y, Nakajima K, Ichinohe T, Nagata T, Chiba T, Tsuruta F. Propagation of neuronal micronuclei regulates microglial characteristics. Nat Neurosci. 28(3):487–498. https://doi.org/10.1038/s41593-024-01863-5 (2025) 

16. Nakatsukasa Y, Yamada Y, Yamada Y. Research of in vivo reprogramming toward clinical applications in regenerative medicine: A concise review. Regenerative therapy. 28:12–19. https://doi.org/10.1016/j.reth.2024.11.008 (2025) 

17. Kobayashi M, Kobayashi N, Deguchi K, Omori S, Ichinohe T. SARS-CoV-2 infection primes cross-protective respiratory IgA in a MyD88- and MAVS-dependent manner. NPJ Vaccines. 10(1):40–z. https://doi.org/10.1038/s41541-025-01095-z (2025)

18. Oka E, Ueda Y, Yagi A, Machida M, Furuse Y, Tabuchi T. Challenges to promoting maternal respiratory syncytial virus vaccination in Japan. Vaccine. 48:126767. https://doi.org/10.1016/j.vaccine.2025.126767 (2025)

19. Lytras S, Lamb KD, Ito J, Grove J, Yuan K, Sato K, Hughes J, Robertson DL. Pathogen genomic surveillance and the AI revolution. J Virol. 99(2):e0160124–24. Epub 2025 Jan 29. https://doi.org/10.1128/jvi.01601-24 (2025)

20. Ise W, Koike T, Shimada N, Yamamoto H, Tai Y, Shirai T, Kawakami R, Kuwabara M, Kawai C, Shida K, Inoue T, Hojo N, Ichiyama K, Sakaguchi S, Shiroguchi K, Suzuki K, Kurosaki T. KLF2 expression in IgG plasma cells at their induction site regulates the migration program. J Exp Med. 222(5):e20241019. https://doi.org/10.1084/jem.20241019 (2025)

論文解説　抗体産生細胞の運命を決める仕組みを解明: 抗体応答が持続するワクチンの開発に期待

21. Suzuki T, Ogizawa A, Ishiguro K, Nagao A. Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases. Cell chemical biology. 32(2):227–238. https://doi.org/10.1016/j.chembiol.2024.11.004 (2025)  

22. Yu X, Ni Z, Wang Y, Wang J, Deng G, Shi J, Kong H, Jiang Y, Tian G, Li C, Kawaoka Y, Chen H, Wang J. Claudin-11 plays a pivotal role in the clathrin-mediated endocytosis of influenza A virus. Sci China Life Sci. https://doi.org/10.1007/s11427-024-2856-y (2025)

23. Furuse Y, Komorizono R, Fujita N. Need to revisit culture isolation for detecting viraemia. Lancet Microbe. :101080. https://doi.org/10.1016/j.lanmic.2025.101080 (2025)

24. Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO. Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP((1,2)) in a position elevated from the virion membrane. Nat Commun. 16(1):1293–2. https://doi.org/10.1038/s41467-025-56452-2 (2025)

25. Uraki R, Ito M, Kiso M, Iwatsuki-Horimoto K, Endo M, Yamayoshi S, Kawaoka Y. An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters. npj Viruses. 3(1):7. https://doi.org/10.1038/s44298-025-00096-y (2025) 

26. Uriu K, Kaku Y, Uwamino Y, Fujiwara H, Saito F, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K. Antiviral humoral immunity induced by JN.1 monovalent mRNA vaccines against SARS-CoV-2 omicron subvariants including JN.1, KP.3.1.1, and XEC. Lancet Infect Dis. 25(2):e61–7. Epub 2024 Dec 10. https://doi.org/10.1016/S1473-3099(24)00810-7 (2025)
    論文解説　オミクロンJN.1mRNAワクチンにより誘導される オミクロン亜株に対する液性免疫の効果

27. Ujiie K, Nakakido M, Kinoshita S, Caaveiro JMM, Entzminger CK, Okumura SCJ, Maruyama T, Miyauchi K, Matano T, Tsumoto K. Specific recognition mechanism of an antibody to sulfated tyrosine and its potential use in biological research. J Biol Chem. 301(2):108176. https://doi.org/10.1016/j.jbc.2025.108176 (2025)

28. Kakizaki M, Hashimoto R, Nagata N, Yamamoto T, Okura T, Katoh H, Kitai Y, Akahori Y, Shirato K, Ryo A, Takayama K, Takeda M. The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids. J Virol. 99(1):e0185324–24. Epub 2024 Nov 27. https://doi.org/10.1128/jvi.01853-24 (2025)

29. Kanno A, Tanifuji R*, Yoshida S, Sato S, Maki-Yonekura S, Takaba K, Kang J, Tono K, Yonekura K, Oguri H. Streamlined modular synthesis of saframycin substructure via copper-catalyzed three-component assembly and gold-promoted 6-endo cyclization. Beilstein Journal of Organic Chemistry. 21:226–233. https://doi.org/10.3762/bjoc.21.14 (2025)

30. Saegusa K, Tsuchida Y, Komai T, Tsuchiya H, Fujio K. Advances in Targeted Therapy for Systemic Lupus Erythematosus: Current Treatments and Novel Approaches. Int J Mol Sci. 26(3):929. doi: 10.3390/ijms26030929. https://doi.org/10.3390/ijms26030929 (2025)

31. Sekine R, Takeda K, Suenaga T, Tsuno S, Kaiya T, Kiso M, Yamayoshi S, Takaku Y, Ohno S, Yamaguchi Y, Nishizawa S, Sumitomo K, Ikuta K, Kanda T, Kawaoka Y, Nishimura H, Kuge S. G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication. Communications Biology. 8(1):27. https://doi.org/10.1038/s42003-024-07351-7 (2025)

32. Imai M, Ueki H, Ito M, Iwatsuki-Horimoto K, Kiso M, Biswas A, Trifkovic S, Cook N, Halfmann PJ, Neumann G, Eisfeld AJ, Kawaoka Y. Highly pathogenic avian H5N1 influenza A virus replication in ex vivo cultures of bovine mammary gland and teat tissues. Emerging Microbes & Infections. 14(1):2450029. https://doi.org/10.1080/22221751.2025.2450029 (2025)
    論文解説　乳牛の乳房・乳頭組織におけるウシ由来H５N1高病原性 鳥インフルエンザウイルスの増殖性状を解明

33. Taguchi J, Yamada Y, Ohta S, Nakasuka F, Yamamoto T, Ozawa M, Yamada Y. A versatile in vivo platform for reversible control of transgene expression in adult tissues. Stem cell reports. 20(1):102373. https://doi.org/10.1016/j.stemcr.2024.11.003 (2025) 

34. Yang J, Song I, Saito M, Hartanto T, Ichinohe T, Fukuda S. Partially hydrolyzed guar gum attenuates symptoms and modulates the gut microbiota in a model of SARS-CoV-2 infection. Gut microbiome (Cambridge, England). 6:e1. https://doi.org/10.1017/gmb.2024.7 (2025)  

35. Ueki H, Wang I, Kiso M, Horie K, Iida S, Mine S, Ujie M, Hsu H, Wu CH, Imai M, Suzuki T, Kamitani W, Kawakami E, Kawaoka Y. Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology. Nat Commun. 16(1):455–0. https://doi.org/10.1038/s41467-024-55272-0 (2025)
    論文解説　免疫細胞が引き起こすCOVID-19の重症化機序を解明: ― 肺血管での異常な接着現象に着目 ―

36. Ishizaka A*, Tamura A, Koga M, Mizutani T, Yamayoshi S, Iwatsuki-Horimoto K, Yasuhara A, Yamamoto S, Nagai H, Adachi E, Suzuki Y, Kawaoka Y, Yotsuyanagi H. Dysbiosis of gut microbiota in COVID-19 is associated with intestinal DNA phage dynamics of lysogenic and lytic infection. Microbiology Spectrum. 13(1) https://doi.org/10.1128/spectrum.00998-24 (2025)

37. Halfmann PJ, Patel RS, Loeffler K, Yasuhara A, van de Velde L, Yang JE, Chervin J, Troxell C, Huang M, Zheng N, Wright ER, Thomas PG, Wilson PC, Kawaoka Y, Kane RS. Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice. Nature Communications. 16(1):462. https://doi.org/10.1038/s41467-025-55824-y (2025)

38. Higashi-Kuwata N, Bulut H, Hayashi H, Tsuji K, Ogata-Aoki H, Kiso M, Takamune N, Kishimoto N, Hattori S, Ishii T, Kobayakawa T, Nakano K, Shimizu Y, Das D, Saruwatari J, Hasegawa K, Murayama K, Sukenaga Y, Takamatsu Y, Yoshimura K, Aoki M, Furusawa Y, Okamura T, Yamayoshi S, Kawaoka Y, Misumi S, Tamamura H, Mitsuya H. An orally available P1'-5-fluorinated M(pro) inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier. PNAS Nexus. 4(1):pgae578. https://doi.org/10.1093/pnasnexus/pgae578 (2025)

39. Gu C, Babujee L, Pattinson D, Chiba S, Jester P, Maemura T, Neumann G, Kawaoka Y. Development of broadly protective influenza B vaccines. NPJ Vaccines. 10(1):2–w. https://doi.org/10.1038/s41541-024-01058-w (2025)

40. Tsutsui M, Tsunekawa Y, Wada M, Arima A, Onodera A, Nishina M, Nagoya M, Baba Y, Kawai T, Okada T. Enhanced Discriminability of Viral Vectors in Viscous Nanopores. Small methods. :e2401321. https://doi.org/10.1002/smtd.202401321 (2025) 

41. Alkhalaf LM, Arrowsmith C, Balskus EP, Bergamini G, Bhandari R, Chang CJ, Chen P, Chen X, Ciulli A, Cricco JA, Davis BG, Delbianco M, Dudareva N, Dueber E, Ferguson F, de Giuseppe PO, Hamachi I, Hammond MC, Hatzios SK, Do Heo W, Janet JP, Kamat SS, Knapp S, Krishnan Y, Lang K, Laraia L, Leveson-Gower RB, Li XD, Liu DR, Liu M, London N, Mahanta N, Mayor-Ruiz C, Muir T, Murakami MT, Rhee H, Robers M, Satz A, Schulman BA, Shen B, Shoichet B, Strauss E, Suzuki T, Tiwary P, Waldmann H, Ward TR, Weeks A, Weerapana E, Winter G. Thoughts for the future. Nat Chem Biol. 21(1):6–15. https://doi.org/10.1038/s41589-024-01802-2 (2025) 

42. Noji H, Minagawa Y, Ueno H. Digital bioassay. Oyo Buturi. 94(1):3–9. https://doi.org/10.11470/oubutsu.94.1_3 (2025)

2024

1. Ishizaka A*, Koga M, Mizutani T, Suzuki Y, Matano T, Yotsuyanagi H. Thiamine deficiency underlies persistent gut dysbiosis and inflammation in people living with HIV on antiretroviral therapy. Translational Medicine Communications. 9(1):25. https://doi.org/10.1186/s41231-024-00187-7 (2024) 

2. Nagamura R, Kujirai T, Kato J, Shuto Y, Kusakizako T, Hirano H, Endo M, Toki S, Saika H, Kurumizaka H, Nureki O. Structural insights into how Cas9 targets nucleosomes. Nat Commun. 15(1):10744–z. https://doi.org/10.1038/s41467-024-54768-z (2024)

3. Amano R, Takahashi M, Haga K, Yamamoto M, Goto K, Ichinose A, Hamada M, Gohda J, Inoue J, Kawaguchi Y, Moi ML, Nakamura Y. A chimeric RNA consisting of siRNA and aptamer for inhibiting dengue virus replication. NAR Mol Med. 1(4):ugae025. https://doi.org/10.1093/narmme/ugae025 (2024)
   論文解説　多機能キメラ核酸によるデングウイルス増殖抑制:  将来の感染症医薬開発へ幅広い応用の可能性

4. Katoh H, Kimura R, Sekizuka T, Matsuoka K, Hosogi M, Kitai Y, Akahori Y, Kato F, Kataoka M, Kobayashi H, Nagata N, Suzuki T, Ohkawa Y, Oki S, Takeda M. Structural and molecular properties of mumps virus inclusion bodies. Science Advances. 10(49):eadr0359. https://doi.org/10.1126/sciadv.adr0359 (2024)
   論文解説　グアニン四重鎖構造を持つRNAがおたふくかぜウイルスのRNA合成の場を提供する: ―おたふくかぜウイルスの封入体形成機構の理解―

5. Kim KQ, Li JJ, Nanjaraj Urs AN, Pacheco ME, Lasehinde V, Denk T, Tesina P, Tomomatsu S, Matsuo Y, McDonald E, Beckmann R, Inada T, Green R, Zaher HS. Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes. Mol Cell. 84(23):4594–4611.e9. https://doi.org/10.1016/j.molcel.2024.10.029 (2024)

6. Ay S, Burlaud-Gaillard J, Gazi A, Tatirovsky Y, Cuche C, Diana J, Scoca V, Di Santo JP, Roingeard P, Mammano F, Di Nunzio F. In vivo HIV-1 nuclear condensates safeguard against cGAS and license reverse transcription. EMBO J. 44(1):166–199. https://doi.org/10.1038/s44318-024-00316-w (2025)

7. Iijima N*, Yamaguchi M, Hayashi T, Rui Y, Ohira Y, Miyamoto Y, Niino M, Okuno T, Suzuki O, Oka M, Ishii KJ. miR-147-3p in pathogenic CD4 T cells controls chemokine receptor expression for the development of experimental autoimmune diseases. J Autoimmun. 149:103319. https://doi.org/10.1016/j.jaut.2024.103319 (2024)

8. Togashi T, Baatartsogt N, Nagao Y, Kashiwakura Y, Hayakawa M, Hiramoto T, Fujiwara T, Morishita E, Nureki O, Ohmori T. Cure of Congenital Purpura Fulminans via Expression of Engineered Protein C Through Neonatal Genome Editing in Mice. Arterioscler Thromb Vasc Biol. 44(12):2616–2627. https://doi.org/10.1161/ATVBAHA.123.319460 (2024)

9. Kobayashi M, Kobayashi N, Deguchi K, Omori S, Nagai M, Fukui R, Song I, Fukuda S, Miyake K, Ichinohe T. TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages. Plos Pathogens. 20(12):e1012776. https://doi.org/10.1371/journal.ppat.1012776 (2024)

10. Zhou NE, Tang S, Bian X, Parai MK, Krieger IV, Flores A, Jaiswal PK, Bam R, Wood JL, Shi Z, Stevens LJ, Scobey T, Diefenbacher MV, Moreira FR, Baric TJ, Acharya A, Shin J, Rathi MM, Wolff KC, Riva L, Bakowski MA, Mcnamara CW, Catanzaro NJ, Graham RL, Schultz DC, Cherry S, Kawaoka Y, Halfmann PJ, Baric RS, Denison MR, Sheahan TP, Sacchettini JC. An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo. Cell Reports. 43(11):114929. https://doi.org/10.1016/j.celrep.2024.114929 (2024)

11. Anzurez A, Runtuwene L, Dang TTT, Nakayama-Hosoya K, Koga M, Yoshimura Y, Sasaki H, Miyata N, Miyazaki K, Takahashi Y, Suzuki T, Yotsuyanagi H, Tachikawa N, Matano T, Kawana-Tachikawa A. Characterization of the Proinflammatory Cytokine Profile during Acute SARS-CoV-2 Infection in People with Human Immunodeficiency Virus. Jpn J Infect Dis. 77(6):301–310. https://doi.org/10.7883/yoken.JJID.2024.184 (2024)

12. Iwatsuki-Horimoto K, Kiso M, Ito M, Yamayoshi S, Kawaoka Y. Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not. npj Viruses. 2(1):59. https://doi.org/10.1038/s44298-024-00068-8 (2024) 

13. Kurata T, Takegawa M, Ohira T, Syroegin EA, Atkinson GC, Johansson MJO, Polikanov YS, Garcia-Pino A, Suzuki T, Hauryliuk V. Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNA Gly and tRNA Thr. Science advances. 10(46):eadr9624. https://doi.org/10.1126/sciadv.adr9624 (2024) 

14. Ota A, Iguchi T, Nitta S, Muro R, Mino N, Tsukasaki M, Penninger JM, Nitta T, Takayanagi H. Synchronized development of thymic eosinophils and thymocytes. Int Immunol. 36(12):617–628. https://doi.org/10.1093/intimm/dxae037 (2024)

15. Tanaka R, Tamao K, Ono M, Yamayoshi S, Kawaoka Y, Su'etsugu M, Noji H, Tabata KV. In vitro one-pot construction of influenza viral genomes for virus particle synthesis based on reverse genetics system. PLoS One. 19(11):e0312776. https://doi.org/10.1371/journal.pone.0312776 (2024)

16. Akichika S, Suzuki T. Cap-specific m6Am modification: A transcriptional anti-terminator by sequestering PCF11 with implications for neuroblastoma therapy. Molecular cell. 84(21):4051–4052. https://doi.org/10.1016/j.molcel.2024.10.014 (2024) 

17. Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei F, Shihoya W, Nureki O. Structural insights into the agonist selectivity of the adenosine A3 receptor. Nature Communications. 15(1):9294. https://doi.org/10.1038/s41467-024-53473-1 (2024)

18. Akasaka H, Sano FK, Shihoya W, Nureki O. Structural mechanisms of potent lysophosphatidic acid receptor 1 activation by nonlipid basic agonists. Commun Biol. 7(1):1444–y. https://doi.org/10.1038/s42003-024-07152-y (2024)

19. Chiba S, Kiso M, Yamada S, Someya K, Onodera Y, Yamaguchi A, Matsunaga S, Jounai N, Yamayoshi S, Takeshita F, Kawaoka Y. Protective effects of an mRNA vaccine candidate encoding H5HA clade 2.3.4.4b against the newly emerged dairy cattle H5N1 virus. eBioMedicine. 109:105408. https://doi.org/10.1016/j.ebiom.2024.105408 (2024) 

論文解説　高病原性鳥インフルエンザH5HAのLNP-mRNAワクチンは牛由来H5N1 ウイルスに対して防御効果を示す

20. Muro R, Nitta T, Nitta S, Tsukasaki M, Asano T, Nakano K, Okamura T, Nakashima T, Okamoto K, Takayanagi H. Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity. J Clin Invest. 134(20):e179612. https://doi.org/10.1172/JCI179612 (2024)

21. Yajima H, Anraku Y, Kaku Y, Kimura KT, Plianchaisuk A, Okumura K, Nakada-Nakura Y, Atarashi Y, Hemmi T, Kuroda D, Takahashi Y, Kita S, Sasaki J, Sumita H, Ito J, Maenaka K, Sato K, Hashiguchi T. Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1. Nature Communications. 15(1):8574. https://doi.org/10.1038/s41467-024-52808-2 (2024)
    論文解説　新型コロナウイルス変異株の構造特性を解明 ―流行株の変化を原子レベルで可視化―

22. Gao P, Morita N, Shinkura R. Role of mucosal IgA antibodies as novel therapies to enhance mucosal barriers. Semin Immunopathol. 47(1):1–4. https://doi.org/10.1007/s00281-024-01027-4 (2024)

23. Shimoyama M, Nakada-Tsukui K, Nozaki T. EhRacM differentially regulates macropinocytosis and motility in the enteric protozoan parasite Entamoeba histolytica. PLoS Pathog. 20(11):e1012364. https://doi.org/10.1371/journal.ppat.1012364 (2024)

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論文解説　自己免疫疾患の制御に関わる新たな加齢関連T細胞を発見

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論文解説　オミクロンXBB.1.5株対応1価ワクチンにより誘導されるオミクロン亜株に対する液性免疫の効果

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論文解説　オミクロンBA.2.86株のウイルス学的特性の解明

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論文解説　オミクロンXBB.1.5のウイルス学的特性の解明 ～新型コロナウイルスの生態の全容解明に貢献すると期待～

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論文解説　SARS-CoV-2オミクロンJN.1株のウイルス学的特性の解明

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2023

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論文解説　新型コロナウイルス・オミクロン株EG.5.1系統は、 ハムスターで初期のオミクロン系統よりも伝播しやすい

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論文解説　ミンク由来高病原性H5N1鳥インフルエンザウイルスの性状解析

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論文解説　SARS-CoV-2オミクロンBA.2.86株の 伝播力、感染性および免疫抵抗性

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論文解説　新型コロナウイルス・オミクロン株のXBB.1.9.1系統は XBB.1.5系統と類似の性状を持つ

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論文解説　SARS-CoV-2 XBBブレイクスルー感染者血清の、 EG.5を含むオミクロン変異株への抗ウイルス作用の解析

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論文解説　インフルエンザウイルスHAの変異し難い部位をねらう　ワクチン抗原のデザイン　 ―ユニバーサルワクチンの新規ストラテジー―

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論文解説　ゾコーバ耐性新型コロナウイルスの性状解析

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論文解説　ニルマトレルビル耐性新型コロナウイルスの性状解析

72. Muramoto Y, Takahashi S, Halfmann PJ, Gotoh S, Noda T, Kawaoka Y. Replicative capacity of SARS-CoV-2 omicron variants BA.5 and BQ.1.1 at elevated temperatures. Lancet Microbe. 4(7):e486-3. Epub 2023 Apr 24. https://doi.org/10.1016/S2666-5247(23)00100-3 (2023)

論文解説　新型コロナウイルス・オミクロン株のBA.5系統およびBQ.1.1系統が、高温で増殖しづらいことを解明

73. Das K, Nozaki T. Non-Vesicular Lipid Transport Machinery in Leishmania donovani: Functional Implications in Host-Parasite Interaction. International Journal of Molecular Sciences. 24(13):10637. https://doi.org/10.3390/ijms241310637 (2023)

74. Nagai M, Moriyama M, Ishii C, Mori H, Watanabe H, Nakahara T, Yamada T, Ishikawa D, Ishikawa T, Hirayama A, Kimura I, Nagahara A, Naito T, Fukuda S, Ichinohe T. High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection. Nat Commun. 14(1):3863. https://doi.org/10.1038/s41467-023-39569-0 (2023) 

論文解説　発熱がウイルス性肺炎の重症化を抑制するメカニズムを解明 ――重症化の抑制には38℃以上の体温で活性化した腸内細菌叢が必要だった――

75. Yamamoto S, Yamayoshi S, Ito M, Sakai-Tagawa Y, Nakachi I, Baba R, Kamimoto S, Ogura T, Hagiwara S, Kato H, Nakajima H, Uwamino Y, Yagi K, Sugaya N, Nagai H, Saito M, Adachi E, Koga M, Tsutsumi T, Duong C, Okuda M, Murakami J, Furusawa Y, Ujie M, Iwatsuki-Horimoto K, Yotsuyanagi H, Kawaoka Y. Differences among epitopes recognized by neutralizing antibodies induced by SARS-CoV-2 infection or COVID-19 vaccination. iScience. 26(7):107208. https://doi.org/10.1016/j.isci.2023.107208 (2023)

76. Halfmann PJ, Uraki R, Kuroda M, Iwatsuki-Horimoto K, Yamayoshi S, Ito M, Kawaoka Y. Transmission and re-infection of Omicron variant XBB.1.5 in hamsters. eBioMedicine. 93:104677. https://doi.org/10.1016/j.ebiom.2023.104677 (2023) 

論文解説　新型コロナウイルス・オミクロン株XBB.1.5系統は、 ハムスターで初期のオミクロン系統よりも伝播しやすい

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83. Tamura D, Kawaoka Y. Omicron proliferation in the nasal cavity may explain its high infectivity. J Infect. 86(6):584-587. https://doi.org/10.1016/j.jinf.2023.03.006 (2023)

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論文解説　SARS-CoV-2オミクロンXBB.1.16株の ウイルス学的特性の解明

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論文解説　液-液相分離体「ストレス顆粒」形成による ストレス防御および癌進展機構の解明 ――ストレス環境下で細胞がアポトーシスを回避する新たな仕組みを発見――

87. Nakamura Y, Moi ML, Shiina T, Shin-I T, Suzuki R. Idiotope-Driven T-Cell/B-Cell Collaboration-Based T-Cell Epitope Prediction Using B-Cell Receptor Repertoire Sequences in Infectious Diseases. Viruses-Basel. 15(5):1186. https://doi.org/10.3390/v15051186 (2023)

88. Nagao A, Nakanishi Y, Yamaguchi Y, Mishina Y, Karoji M, Toya T, Fujita T, Iwasaki S, Miyauchi K, Sakaguchi Y, Suzuki T. Quality control of protein synthesis in the early elongation stage. Nat Commun. 14(1):2704-5. https://doi.org/10.1038/s41467-023-38077-5 (2023)

89. Shibata K, Oda K, Nishizawa T, Hazama Y, Ono R, Takaramoto S, Bagherzadeh R, Yawo H, Nureki O, Inoue K, Akiyama H. Twisting and Protonation of Retinal Chromophore Regulate Channel Gating of Channelrhodopsin C1C2. J Am Chem Soc. 145(19):10779-10789. https://doi.org/10.1021/jacs.3c01879 (2023)

90. Tamura T, Ito J, Uriu K, Zahradnik J, Kida I, Anraku Y, Nasser H, Shofa M, Oda Y, Lytras S, Nao N, Itakura Y, Deguchi S, Suzuki R, Wang L, Begum MM, Kita S, Yajima H, Sasaki J, Sasaki-Tabata K, Shimizu R, Tsuda M, Kosugi Y, Fujita S, Pan L, Sauter D, Yoshimatsu K, Suzuki S, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Schreiber G, Maenaka K, Genotype to Phenotype Japan (G2P-Japan) Consortium, Hashiguchi T, Ikeda T, Fukuhara T, Saito A, Tanaka S, Matsuno K, Takayama K, Sato K. Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants. Nat Commun. 14(1):2800-3. https://doi.org/10.1038/s41467-023-38435-3 (2023)

論文解説　オミクロンXBB株の進化経路とウイルス学的特性の解明 ―遺伝子組換えによる更なる免疫逃避能力の獲得―

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論文解説　SARS-CoV-2オミクロン株の進化パターンの一端を解明 ―スパイクタンパク質の収斂進化が適応度の高い変異株の出現に繋がる―

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論文解説　BA.4/5株対応2価mRNAワクチン接種で、 新型コロナウイルス・オミクロン株XBF系統に対する 中和活性は増強される

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論文解説　新型コロナウイルス・オミクロン株のCH.1.1系統に対する 治療薬と2価ワクチンの効果を検証

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論文解説　新型コロナウイルス・デルタ変異株の Spike-P681RおよびD950N変異の機能解析

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98. Chowdhury SI, Inui M, Yamazaki T, Tomono S, Takagi H, Biswas M, Saitoh S, Miyake K, Akashi-Takamura S. The anti-TLR4 monoclonal antibody Sa15-21 enhances inflammatory cytokine production in LPS-stimulated macrophages. FEBS Lett. 597(9):1246-1260. https://doi.org/10.1002/1873-3468.14619 (2023)

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100. Guan L, Zhong G, Fan S, Plisch EM, Presler R, Gu C, Babujee L, Pattinson D, Le Khanh Nguyen H, Hoang VMP, Le MQ, van Bakel H, Neumann G, Kawaoka Y. Highly Pathogenic H5 Influenza Viruses Isolated between 2016 and 2017 in Vietnamese Live Bird Markets. Viruses-Basel. 15(5):1093. https://doi.org/10.3390/v15051093 (2023)

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論文解説　新型コロナウイルス・オミクロン株のXBB.1.5系統に対する 治療薬とワクチンの効果を検証

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News Release　Study reveals the 3D structure of a protein involved in genome editing

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論文解説　新型コロナウイルス・オミクロン変異株のBA.2.75系統の性状解析

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論文解説　SARS-CoV-2オミクロンXBB.1.5株のウイルス学的性状の解明

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124. Kiso M, Uraki R, Ito M, Yamayoshi S, Kotani Y, Imai M, Kohda N, Kawaoka Y. Oral intake of heat-killed Lactiplantibacillus pentosus ONRICb0240 partially protects mice against SARS-CoV-2 infection. Frontiers in Virology. 3:1137133. https://doi.org/10.3389/fviro.2023.1137133 (2023)

125. Kuchitsu Y, Mukai K, Uematsu R, Takaada Y, Shinojima A, Shindo R, Shoji T, Hamano S, Ogawa E, Sato R, Miyake K, Kato A, Kawaguchi Y, Nishitani-Isa M, Izawa K, Nishikomori R, Yasumi T, Suzuki T, Dohmae N, Uemura T, Barber GN, Arai H, Waguri S, Taguchi T. STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes. Nat Cell Biol. 25(3):453-466. https://doi.org/10.1038/s41556-023-01098-9 (2023)

126. Okamoto K, Takayanagi H. Effect of T cells on bone. Bone. 168:116675. https://doi.org/10.1016/j.bone.2023.116675 (2023)

127. Wijaya TJ, Yokota T, Lee S, Okano R, Kobayashi M, Someya T. Photostability Improvement of Organic Photodiodes with ZnO Electron Transport Layer. Adv Photon Res. 4(3) https://doi.org/10.1002/adpr.202200355 (2023)

128. Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori S, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H. Identification of SARS-CoV-2 M(pro) inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nat Commun. 14(1):1076-0. https://doi.org/10.1038/s41467-023-36729-0 (2023)

129. McLean HQ, Petrie JG, Hanson KE, Meece JK, Rolfes MA, Sylvester GC, Neumann G, Kawaoka Y, Belongia EA. Interim Estimates of 2022-23 Seasonal Influenza Vaccine Effectiveness - Wisconsin, October 2022-February 2023. MMWR Morb Mortal Wkly Rep. 72(8):201-205. https://doi.org/10.15585/mmwr.mm7208a1 (2023)

130. Yotsuyanagi H, Ohmagari N, Doi Y, Imamura T, Sonoyama T, Ichihashi G, Sanaki T, Tsuge Y, Uehara T, Mukae H. A phase 2/3 study of S-217622 in participants with SARS-CoV-2 infection (Phase 3 part). Medicine (Baltimore). 102(8):e33024. https://doi.org/10.1097/MD.0000000000033024 (2023)

131. Nakayama T, Azegami T, Kiso M, Imai M, Uraki R, Hayashi K, Hishikawa A, Yoshimoto N, Nakamichi R, Sugita-Nishimura E, Yoshida-Hama E, Kawaoka Y, Itoh H. Plasminogen activator inhibitor 1 is not a major causative factor for exacerbation in a mouse model of SARS-CoV-2 infection. Sci Rep. 13(1):3103-8. https://doi.org/10.1038/s41598-023-30305-8 (2023)

132. Iwatsuki-Horimoto K, Ueki H, Ito M, Nagasawa S, Hirata Y, Hashizume K, Ushiwata K, Iwase H, Makino Y, Ushiku T, Akitomi S, Imai M, Saitoh H, Kawaoka Y. SARS-CoV-2 Transmission from Virus-Infected Dead Hamsters. mSphere. 8(1):e0041122-22. Epub 2023 Jan 10. https://doi.org/10.1128/msphere.00411-22 (2023)

論文解説　SARS-CoV-2感染動物死体からのウイルス伝播

133. Yoshioka Y, Kobiyama K, Hayashi T, Onishi M, Yanagida Y, Nakagawa T, Hashimoto M, Nishinaka A, Hirose J, Asaoka Y, Tajiri M, Hayata A, Ishida S, Omoto S, Nagira M, Ishii KJ. A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via alpha-tocopherol component. Front Immunol. 14:1116238. https://doi.org/10.3389/fimmu.2023.1116238 (2023)

134. Best K, Ikeuchi K, Kater L, Best D, Musial J, Matsuo Y, Berninghausen O, Becker T, Inada T, Beckmann R. Structural basis for clearing of ribosome collisions by the RQT complex. Nat Commun. 14(1):921-8. https://doi.org/10.1038/s41467-023-36230-8 (2023)

論文解説　異常翻訳の実体である衝突リボソームの解消機構 ――mRNA引っ張り力によるリボソーム構造変化による異常翻訳解消機構――

135. Tesina P, Ebine S, Buschauer R, Thoms M, Matsuo Y, Inada T, Beckmann R. Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol Cell. 83(4):607-621.e4. https://doi.org/10.1016/j.molcel.2023.01.020 (2023)

論文解説　非典型翻訳反応における翻訳因子eIF5Aの機能の解明 ――mRNAを必要とせずにペプチド合成反応を行う仕組み――

136. Soga T, Duong C, Pattinson D, Sakai-Tagawa Y, Tokita A, Izumida N, Nishino T, Hagiwara H, Wada N, Miyamoto Y, Kuroki H, Hayashi Y, Seki M, Kasuya N, Koga M, Adachi E, Iwatsuki-Horimoto K, Yotsuyanagi H, Yamayoshi S, Kawaoka Y. Characterization of Influenza A(H1N1)pdm09 Viruses Isolated in the 2018-2019 and 2019-2020 Influenza Seasons in Japan. Viruses. 15(2):535. https://doi.org/10.3390/v15020535 (2023)

137. Mahita J, Ha B, Gambiez A, Schendel SL, Li H, Hastie KM, Dennison SM, Li K, Kuzmina N, Periasamy S, Bukreyev A, Munt JE, Osei-Twum M, Atyeo C, Overton JA, Vita R, Guzman-Orozco H, Mendes M, Kojima M, Halfmann PJ, Kawaoka Y, Alter G, Gagnon L, Baric RS, Tomaras GD, Germann T, Bedinger D, Greenbaum JA, Saphire EO, Peters B. Coronavirus Immunotherapeutic Consortium Database. Database (Oxford). 2023:10.1093/database/baac112. https://doi.org/10.1093/database/baac112 (2023)

138. Sakuma M, Honda S, Ueno H, Tabata KV, Miyazaki K, Tokuriki N, Noji H. Genetic Perturbation Alters Functional Substates in Alkaline Phosphatase. Journal of the American Chemical Society. 145(5):2806–2814. https://doi.org/10.1021/jacs.2c06693 (2023) 

139. Miyashita R, Nishiyama A, Qin W, Chiba Y, Kori S, Kato N, Konishi C, Kumamoto S, Kozuka-Hata H, Oyama M, Kawasoe Y, Tsurimoto T, Takahashi TS, Leonhardt H, Arita K, Nakanishi M. The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Elife. 12:10.7554/eLife.79013. https://doi.org/10.7554/eLife.79013 (2023)

140. Chen S, Quan DH, Sam G, Ozberk V, Wang XT, Halfmann P, Pandey M, Good MF, Kawaoka Y, Britton WJ, Rehm BHA. Assembly of Immunogenic Protein Particles toward Advanced Synthetic Vaccines. Small. 19(8):e2205819. https://doi.org/10.1002/smll.202205819 (2023)

141. Sugimori Y, Iwasaki Y, Takeshima Y, Okubo M, Kobayashi S, Hatano H, Yamada S, Nakano M, Yoshida R, Ota M, Tsuchida Y, Nagafuchi Y, Shimane K, Yoshida K, Kurosaka D, Sumitomo S, Shoda H, Yamamoto K, Okamura T, Fujio K. Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of Myositis-Specific Antibody-Positive Inflammatory Myopathies. ACR Open Rheumatol. 5(2):93-102. https://doi.org/10.1002/acr2.11521 (2023)

142. Watanabe N, Nakada-Tsukui K, Nozaki T. Molecular Dissection of Phagocytosis by Proteomic Analysis in Entamoeba histolytica. Genes. 14(2):379. https://doi.org/10.3390/genes14020379 (2023) 

143. Neumann G, Kawaoka Y. The COVID-19 Pandemic-A Potential Role for Antivirals in Mitigating Pandemics. Viruses. 15(2):303. https://doi.org/10.3390/v15020303 (2023)

144. Braun KM, Haddock Iii LA, Crooks CM, Barry GL, Lalli J, Neumann G, Watanabe T, Imai M, Yamayoshi S, Ito M, Moncla LH, Koelle K, Kawaoka Y, Friedrich TC. Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals. Virus Evol. 9(1):vead004. https://doi.org/10.1093/ve/vead004 (2023)

145. Ly MHP, Nguyen CT, Nguyen TV, Nguyen TTN, Nabeshima T, Adungo F, Takamatsu Y, Huy NT, Le TQM, Morita K, Hasebe F, Moi ML. Differential Infectivity of Human Neural Cell Lines by a Dengue Virus Serotype-3 Genotype-III with a Distinct Nonstructural Protein 2A (NS2A) Amino Acid Substitution Isolated from the Cerebrospinal Fluid of a Dengue Encephalitis Patient. Can J Infect Dis Med Microbiol. 2023:2635383. https://doi.org/10.1155/2023/2635383 (2023)

146. Muro R, Narita T, Nitta T, Takayanagi H. Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation. Front Immunol. 13:1045881. https://doi.org/10.3389/fimmu.2022.1045881 (2023)

147. Moritoyo T, Nishimura N, Hasegawa K, Ishii S, Kirihara K, Takata M, Svensson AK, Umeda-Kameyama Y, Kawarasaki S, Ihara R, Sakanaka C, Wakabayashi Y, Niizuma K, Tominaga T, Yamazaki T, Hasumi K. A first-in-human study of the anti-inflammatory profibrinolytic TMS-007, an SMTP family triprenyl phenol. Br J Clin Pharmacol. https://doi.org/10.1111/bcp.15651 (2023)

148. Matsuo Y, Uchihashi T, Inada T. Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex. Nat Commun. 14(1):79-4. https://doi.org/10.1038/s41467-022-35608-4 (2023)

論文解説　リボソームの異常な交通渋滞を選別するしくみを解明 ――高速AFMを用いて品質管理を司る複合体の動きを可視化――

149. Minagawa Y, Nakata S, Date M, Ii Y, Noji H. On-Chip Enrichment System for Digital Bioassay Based on Aqueous Two-Phase System. ACS Nano. 17(1):212-220. https://doi.org/10.1021/acsnano.2c06007 (2023)

150. Neumann G, Kawaoka Y. Which Virus Will Cause the Next Pandemic? Viruses. 15(1):199. https://doi.org/10.3390/v15010199 (2023)

151. Yoshitaka Matsuo, Takayuki Uchihashi, Toshifumi Inada. Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex. Nature Communications. 14(1):79. https://doi.org/10.1038/s41467-022-35608-4 (2023) 

152. Chiba S, Hatta M, Pattinson D, Yasuhara A, Neumann G, Kawaoka Y. Ferret model to mimic the sequential exposure of humans to historical H3N2 influenza viruses. Vaccine. 41(2):590-597. https://doi.org/10.1016/j.vaccine.2022.12.005 (2023)

153. Imai M, Ito M, Kiso M, Yamayoshi S, Uraki R, Fukushi S, Watanabe S, Suzuki T, Maeda K, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Halfmann PJ, Kawaoka Y. Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB. N Engl J Med. 388(1):89-91. https://doi.org/10.1056/NEJMc2214302 (2023)

論文解説　臨床検体から分離した新型コロナウイルス・オミクロン株の BQ.1.1系統とXBB系統に対する治療薬の効果を検証

154. Jin J, Ogawa T, Hojo N, Kryukov K, Shimizu K, Ikawa T, Imanishi T, Okazaki T, Shiroguchi K. Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes. Proc Natl Acad Sci U S A. 120(1):e2210283120. https://doi.org/10.1073/pnas.2210283120 (2023)

155. Takashita E, Watanabe S, Hasegawa H, Kawaoka Y. Are twindemics occurring? Influenza Other Respir Viruses. 17(1):e13090. https://doi.org/10.1111/irv.13090 (2023)

論文解説　新型コロナウイルス感染症とインフルエンザが同時流行しているかを検証

156. Bae C, Katoh H, Wakata A, Sakata M, Kato F, Takeda M. Demonstration of bacterium-free very rapid reverse genetics system using mumps virus. Microbiol Immunol. 67(1):44-47. https://doi.org/10.1111/1348-0421.13032 (2023)

157. Koga M, Iwatsuki-Horimoto K, Kikuchi T, Yamayoshi S, Kawaoka Y, Yotsuyanagi H. Previous omicron infection may be protective against reinfection with omicron variant BA.5 for at least 5 months. Clin Microbiol Infect. 29(1):120-121. https://doi.org/10.1016/j.cmi.2022.09.009 (2023)

158. Uraki R, Ito M, Furusawa Y, Yamayoshi S, Iwatsuki-Horimoto K, Adachi E, Saito M, Koga M, Tsutsumi T, Yamamoto S, Otani A, Kiso M, Sakai-Tagawa Y, Ueki H, Yotsuyanagi H, Imai M, Kawaoka Y. Humoral immune evasion of the omicron subvariants BQ.1.1 and XBB. Lancet Infect Dis. 23(1):30-32. https://doi.org/10.1016/S1473-3099(22)00816-7 (2023)

論文解説　ワクチン被接種者あるいはブレイクスルー感染者血漿の、 臨床検体から分離した新型コロナウイルス・オミクロン株の BQ.1.1系統とXBB系統に対する反応性を検証

159. Furuya G, Katoh H, Atsumi S, Hashimoto I, Komura D, Hatanaka R, Senga S, Hayashi S, Akita S, Matsumura H, Miura A, Mita H, Nakakido M, Nagatoishi S, Sugiyama A, Suzuki R, Konishi H, Yamamoto A, Abe H, Hiraoka N, Aoki K, Kato Y, Seto Y, Yoshimura C, Miyadera K, Tsumoto K, Ushiku T, Ishikawa S. Nucleic acid-triggered tumoral immunity propagates pH-selective therapeutic antibodies through tumor-driven epitope spreading. Cancer Sci. 114(1):321-338. https://doi.org/10.1111/cas.15596 (2023)

160. Atsumi Y, Toriyama M, Kato H, Nakamura M, Morita A, Takaishi M, Saito K, Tanaka M, Okada F, Tominaga M, Ishii KJ, Fujita F. Anti-Inflammatory Role of TRPV4 in Human Macrophages. Immunohorizons. 7(1):81-96. https://doi.org/10.4049/immunohorizons.2200100 (2023) 

161. 塚崎 雅之, 高柳 広. 【最新の骨粗鬆症学(第2版)-骨粗鬆症学の最新知見-】骨研究フロンティア　骨代謝を調節する微細環境　免疫系. 日臨. 81(増刊1 最新の骨粗鬆症学):111-117. (2023) 

162. 鶴町 真也, 平野 利忠, 山田 泰広. 生体内リプログラミングによる膵島細胞の増殖誘導. 医学のあゆみ. 284(11):885-889. (2023) https://cir.nii.ac.jp/crid/1520577215748432768

2022

1. Tomomatsu S, Watanabe A, Tesina P, Hashimoto S, Ikeuchi K, Li S, Matsuo Y, Beckmann R, Inada T. Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay. Nucleic Acids Res. 51(1):253-270. https://doi.org/10.1093/nar/gkac1172 (2022)

論文解説　リボソーム衝突に依存したmRNAの内部切断の仕組み

2. Eiden J, Fierro C, Schwartz H, Adams M, Ellis KJ, Aitchison R, Herber R, Hatta Y, Marshall D, Moser MJ, Belshe R, Greenberg H, Coelingh K, Kawaoka Y, Neumann G, Bilsel P. Intranasal M2SR (M2-Deficient Single Replication) H3N2 Influenza Vaccine Provides Enhanced Mucosal and Serum Antibodies in Adults. J Infect Dis. 227(1):103-112. https://doi.org/10.1093/infdis/jiac433 (2022)

3. Takeshita M, Fukuyama H, Kamada K, Matsumoto T, Makino-Okamura C, Uchikubo-Kamo T, Tomabechi Y, Hanada K, Moriyama S, Takahashi Y, Ishigaki H, Nakayama M, Nguyen CT, Kitagawa Y, Itoh Y, Imai M, Maemura T, Furusawa Y, Ueki H, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Kawaoka Y, Shirouzu M, Ishii M, Saya H, Kondo Y, Kaneko Y, Suzuki K, Fukunaga K, Takeuchi T. Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models. iScience. 25(12):105596. https://doi.org/10.1016/j.isci.2022.105596 (2022)

4. Takeshima K, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y. Redundant and Specific Roles of A-Type Lamins and Lamin B Receptor in Herpes Simplex Virus 1 Infection. J Virol. 96(24):1429. https://doi.org/10.1128/jvi.01429-22 (2022)

5. Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada H, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat Commun. 13(1):7857-0. https://doi.org/10.1038/s41467-022-35501-0 (2022)

6. Kawasaki T, Ikegawa M, Yunoki K, Otani H, Ori D, Ishii KJ, Kuroda E, Takamura S, Kitabatake M, Ito T, Isotani A, Kawai T. Alveolar macrophages instruct CD8(+) T cell expansion by antigen cross-presentation in lung. Cell Rep. 41(11):111828. https://doi.org/10.1016/j.celrep.2022.111828 (2022)

7. Sarawar S, Gabaglia CR, Sanchez A, Hatta Y, Dias P, Neumann G, Kawaoka Y, Bilsel P. Longevity and Mechanism of Heterosubtypic Protection Induced by M2SR (M2-Deficient Single-Replication) Live Influenza Virus Vaccine in Mice. Vaccines (Basel). 10(12):2131. doi: 10.3390/vaccines10122131. https://doi.org/10.3390/vaccines10122131 (2022)

8. Ohe S, Kubota Y, Yamaguchi K, Takagi Y, Nashimoto J, Kozuka-Hata H, Oyama M, Furukawa Y, Takekawa M. ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II. Nat Commun. 13(1):7476-4. https://doi.org/10.1038/s41467-022-35230-4 (2022)

論文解説　細胞増殖と発癌を司る初期応答遺伝子群の新たな発現調節機構の解明 ―増殖シグナルがRNAポリメラーゼIIの転写伸長反応を制御する仕組みを発見―

9. Boon ACM, Darling TL, Halfmann PJ, Franks J, Webby RJ, Barouch DH, Port JR, Munster VJ, Diamond MS, Kawaoka Y. Reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters. PLoS Pathog. 18(12):e1010970. https://doi.org/10.1371/journal.ppat.1010970 (2022)

10. Uraki R, Halfmann PJ, Iida S, Yamayoshi S, Furusawa Y, Kiso M, Ito M, Iwatsuki-Horimoto K, Mine S, Kuroda M, Maemura T, Sakai-Tagawa Y, Ueki H, Li R, Liu Y, Larson D, Fukushi S, Watanabe S, Maeda K, Pekosz A, Kandeil A, Webby RJ, Wang Z, Imai M, Suzuki T, Kawaoka Y. Characterization of SARS-CoV-2 Omicron BA.4 and BA.5 isolates in rodents. Nature. 612(7940):540-545. https://doi.org/10.1038/s41586-022-05482-7 (2022)

論文解説　患者から分離した新型コロナウイルス・オミクロン変異株のBA.4系統ならびにBA.5系統の性状解明

11. Tsukamoto Y, Kurogi S, Shibata T, Suzuki K, Hirashita Y, Fumoto S, Yano S, Yanagihara K, Nakada C, Mieno F, Kinoshita K, Fuchino T, Mizukami K, Ueda Y, Etoh T, Uchida T, Hanada T, Takekawa M, Daa T, Shirao K, Hironaka S, Murakami K, Inomata M, Hijiya N, Moriyama M. Enhanced phosphorylation of c-Jun by cisplatin treatment as a potential predictive biomarker for cisplatin response in combination with patient-derived tumor organoids. Lab Invest. 102(12):1355-1366. https://doi.org/10.1038/s41374-022-00827-2 (2022)

12. Takashita E, Yamayoshi S, Halfmann P, Wilson N, Ries H, Richardson A, Bobholz M, Vuyk W, Maddox R, Baker DA, Friedrich TC, O'Connor DH, Uraki R, Ito M, Sakai-Tagawa Y, Adachi E, Saito M, Koga M, Tsutsumi T, Iwatsuki-Horimoto K, Kiso M, Yotsuyanagi H, Watanabe S, Hasegawa H, Imai M, Kawaoka Y. In Vitro Efficacy of Antiviral Agents against Omicron Subvariant BA.4.6. N Engl J Med. 387(22):2094-2097. https://doi.org/10.1056/NEJMc2211845 (2022)

13. Murakami S, Kitamura T, Matsugo H, Kamiki H, Oyabu K, Sekine W, Takenaka-Uema A, Sakai-Tagawa Y, Kawaoka Y, Horimoto T. Isolation of Bat Sarbecoviruses, Japan. Emerg Infect Dis. 28(12):2500-2503. https://doi.org/10.3201/eid2812.220801 (2022)

14. Halfmann PJ, Frey SJ, Loeffler K, Kuroda M, Maemura T, Armbrust T, Yang JE, Hou YJ, Baric R, Wright ER, Kawaoka Y, Kane RS. Multivalent S2-based vaccines provide broad protection against SARS-CoV-2 variants of concern and pangolin coronaviruses. EBioMedicine. 86:104341. https://doi.org/10.1016/j.ebiom.2022.104341 (2022)

15. Hata K, Kobayashi N, Sugimura K, Qin W, Haxholli D, Chiba Y, Yoshimi S, Hayashi G, Onoda H, Ikegami T, Mulholland CB, Nishiyama A, Nakanishi M, Leonhardt H, Konuma T, Arita K. Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger. Nucleic Acids Res. 50(21):12527-12542. https://doi.org/10.1093/nar/gkac1082 (2022)

16. Nagai H, Saito M, Adachi E, Sakai-Tagawa Y, Yamayoshi S, Kiso M, Kawamata T, Koga M, Kawaoka Y, Tsutsumi T, Yotsuyanagi H. Casirivimab/Imdevimab for Active COVID-19 Pneumonia Which Persisted for Nine Months in a Patient with Follicular Lymphoma during Anti-CD20 Therapy. Jpn J Infect Dis. 75(6):608-611. https://doi.org/10.7883/yoken.JJID.2022.092 (2022)

17. Otsubo R, Minamitani T, Kobiyama K, Fujita J, Ito T, Ueno S, Anzai I, Tanino H, Aoyama H, Matsuura Y, Namba K, Imadome K, Ishii KJ, Tsumoto K, Kamitani W, Yasui T. Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein. Sci Rep. 12(1):20120-4. https://doi.org/10.1038/s41598-022-24730-4 (2022)

18. Kikuchi A, Onoda H, Yamaguchi K, Kori S, Matsuzawa S, Chiba Y, Tanimoto S, Yoshimi S, Sato H, Yamagata A, Shirouzu M, Adachi N, Sharif J, Koseki H, Nishiyama A, Nakanishi M, Defossez P, Arita K. Structural basis for activation of DNMT1. Nat Commun. 13(1):7130-4. https://doi.org/10.1038/s41467-022-34779-4 (2022)

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20. Yasuhara A, Yamayoshi S, Kiso M, Sakai-Tagawa Y, Okuda M, Kawaoka Y. A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases. Nat Commun. 13(1):6602-0. https://doi.org/10.1038/s41467-022-34521-0 (2022)

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論文解説　抗PD1抗体は老化細胞の免疫監視を強化し、老年病・生活習慣病を改善する

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論文解説　哺乳類においてリボソームの衝突に対処する仕組み ―ユビキチン修飾を介した翻訳停滞の解消を試験管内で再現―

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