研究

2024　 (as of 11 March 2024)

1. Kosugi Y, Kaku Y, Hinay AAJ, Guo Z, Uriu K, Kihara M, Saito F, Uwamino Y, Kuramochi J, Shirakawa K, Takaori-Kondo A, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K. Antiviral humoral immunity against SARS-CoV-2 omicron subvariants induced by XBB.1.5 monovalent vaccine in infection-naive and XBB-infected individuals. Lancet Infect Dis. 24(3):e147-e148. https://doi.org/10.1016/S1473-3099(23)00784-3 (2024)

論文解説　オミクロンXBB.1.5株対応1価ワクチンにより誘導されるオミクロン亜株に対する液性免疫の効果

2. Ando Y, Tsukasaki M, Huynh NC, Zang S, Yan M, Muro R, Nakamura K, Komagamine M, Komatsu N, Okamoto K, Nakano K, Okamura T, Yamaguchi A, Ishihara K, Takayanagi H. The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis. Int J Oral Sci. 16(1):18-8. https://doi.org/10.1038/s41368-023-00275-8 (2024)

3. Gu C, Fan S, Dahn R, Babujee L, Chiba S, Guan L, Maemura T, Pattinson D, Neumann G, Kawaoka Y. Characterization of a human H3N8 influenza virus. EBioMedicine. 101:105034. https://doi.org/10.1016/j.ebiom.2024.105034 (2024)

4. Nobe M, Maruzuru Y, Takeshima K, Koyanagi N, Kato A, Kawaguchi Y. MYBBP1A is required for efficient replication and gene expression of herpes simplex virus 1. Microbiol Immunol. https://doi.org/10.1111/1348-0421.13120 (2024)

5. Fan S, Kong H, Babujee L, Presler R,Jr, Jester P, Burke D, Pattinson D, Barr I, Smith D, Neumann G, Kawaoka Y. Assessment of the antigenic evolution of a clade 6B.1 human H1N1pdm influenza virus revealed differences between ferret and human convalescent sera. EBioMedicine. 101:105013. https://doi.org/10.1016/j.ebiom.2024.105013 (2024)

6. Tamura T, Mizuma K, Nasser H, Deguchi S, Padilla-Blanco M, Oda Y, Uriu K, Tolentino JEM, Tsujino S, Suzuki R, Kojima I, Nao N, Shimizu R, Wang L, Tsuda M, Jonathan M, Kosugi Y, Guo Z, Hinay AAJ, Putri O, Kim Y, Tanaka YL, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito A, Ito J, Irie T, Tanaka S, Zahradnik J, Ikeda T, Takayama K, Matsuno K, Fukuhara T, Sato K. Virological characteristics of the SARS-CoV-2 BA.2.86 variant. Cell Host Microbe. 32(2):170-180.e12. https://doi.org/10.1016/j.chom.2024.01.001 (2024)

論文解説　オミクロンBA.2.86株のウイルス学的特性の解明

7. Halfmann PJ, Loeffler K, Duffy A, Kuroda M, Yang JE, Wright ER, Kawaoka Y, Kane RS. Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine. Nat Commun. 15(1):1284-6. https://doi.org/10.1038/s41467-024-45495-6 (2024)

8. Tamura T, Irie T, Deguchi S, Yajima H, Tsuda M, Nasser H, Mizuma K, Plianchaisuk A, Suzuki S, Uriu K, Begum MM, Shimizu R, Jonathan M, Suzuki R, Kondo T, Ito H, Kamiyama A, Yoshimatsu K, Shofa M, Hashimoto R, Anraku Y, Kimura KT, Kita S, Sasaki J, Sasaki-Tabata K, Maenaka K, Nao N, Wang L, Oda Y, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ikeda T, Saito A, Matsuno K, Ito J, Tanaka S, Sato K, Hashiguchi T, Takayama K, Fukuhara T. Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant. Nat Commun. 15(1):1176-3. https://doi.org/10.1038/s41467-024-45274-3 (2024)

論文解説　オミクロンXBB.1.5のウイルス学的特性の解明 ～新型コロナウイルスの生態の全容解明に貢献すると期待～

9. Izume T, Kawahara R, Uwamizu A, Chen L, Yaginuma S, Omi J, Kawana H, Hou F, Sano FK, Tanaka T, Kobayashi K, Okamoto HH, Kise Y, Ohwada T, Aoki J, Shihoya W, Nureki O. Structural basis for lysophosphatidylserine recognition by GPR34. Nat Commun. 15(1):902-z. https://doi.org/10.1038/s41467-024-45046-z (2024)

10. Kaku Y, Padilla-Blanco M, Kosugi Y, Uriu K, Hinay AAJ, Chen L, Plianchaisuk A, Kobiyama K, Ishii KJ, Genotype to Phenotype Japan (G2P-Japan) Consortium, Zahradnik J, Ito J, Sato K. Virological characteristics of the SARS-CoV-2 JN.1 variant. Lancet Infect Dis. 24(2):e82-7. Epub 2024 Jan 3. https://doi.org/10.1016/S1473-3099(23)00813-7 (2024)

論文解説　SARS-CoV-2オミクロンJN.1株のウイルス学的特性の解明

11. Belongia EA, Petrie JG, Feldstein LR, Guan L, Halfmann PJ, King JP, Neumann G, Pattinson D, Rolfes MA, McLean HQ, Kawaoka Y. Neutralizing Immunity Against Antigenically Advanced Omicron BA.5 in Children After SARS-CoV-2 Infection. J Pediatric Infect Dis Soc. 13(1):100-104. https://doi.org/10.1093/jpids/piad109 (2024)

12. Yamayoshi S, Nagai E, Mitamura K, Hagihara M, Kobayashi R, Takahashi S, Shibata A, Uwamino Y, Hasegawa N, Iqbal A, Kamimaki I, Iwatsuki-Horimoto K, Nagamura-Inoue T, Kawaoka Y. Seroprevalence of severe acute respiratory syndrome coronavirus 2 N antibodies between December 2021 and march 2023 in Japan. Epidemiol Infect. 152:e24. https://doi.org/10.1017/S0950268824000141 (2024)

13. Oshima HS, Sano FK, Akasaka H, Iwama A, Shihoya W, Nureki O. Optimizing cryo-EM structural analysis of G(i)-coupling receptors via engineered G(t) and Nb35 application. Biochem Biophys Res Commun. 693:149361. https://doi.org/10.1016/j.bbrc.2023.149361 (2024)

14. Maruki T, Nomoto H, Iwamoto N, Yamamoto K, Kurokawa M, Iwatsuki-Horimoto K, Yamayoshi S, Suzuki Y, Kawaoka Y, Ohmagari N. Successful management of persistent COVID-19 using combination antiviral therapy (nirmatrelvir/ritonavir and remdesivir) and intravenous immunoglobulin transfusion in an immunocompromised host who had received CD20 depleting therapy for follicular lymphoma. J Infect Chemother. https://doi.org/10.1016/j.jiac.2024.01.008 (2024)

15. Kosugi Y, Plianchaisuk A, Putri O, Uriu K, Kaku Y, Hinay AAJ, Chen L, Kuramochi J, Sadamasu K, Yoshimura K, Asakura H, Nagashima M, Ito J, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K. Characteristics of the SARS-CoV-2 omicron HK.3 variant harbouring the FLip substitution. Lancet Microbe. https://doi.org/10.1016/S2666-5247(23)00373-7 (2024)

16. Whitworth IT, Knoener RA, Puray-Chavez M, Halfmann P, Romero S, Baddouh M, Scalf M, Kawaoka Y, Kutluay SB, Smith LM, Sherer NM. Defining Distinct RNA-Protein Interactomes of SARS-CoV-2 Genomic and Subgenomic RNAs. J Proteome Res. 23(1):149-160. https://doi.org/10.1021/acs.jproteome.3c00506 (2024)

17. Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK. Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors. Science. 383(6678):101-108. https://doi.org/10.1126/science.adj3347 (2024)

18. Ishizaka A, Koga M, Mizutani T, Yamayoshi S, Iwatsuki-Horimoto K, Adachi E, Suzuki Y, Kawaoka Y, Yotsuyanagi H. Association of gut microbiota with the pathogenesis of SARS-CoV-2 Infection in people living with HIV. BMC Microbiol. 24(1):6-5. https://doi.org/10.1186/s12866-023-03157-5 (2024)

19. Uraki R, Imai M, Ito M, Yamayoshi S, Kiso M, Jounai N, Miyaji K, Iwatsuki-Horimoto K, Takeshita F, Kawaoka Y. An mRNA vaccine encoding the SARS-CoV-2 receptor-binding domain protects mice from various Omicron variants. NPJ Vaccines. 9(1):4-0. https://doi.org/10.1038/s41541-023-00800-0 (2024)

20. Hagihara M, Hayashi H, Nakashima S, Imai Y, Nakano H, Uchida T, Inoue M, Sakai-Tagawa Y, Ito M, Yamayoshi S, Iwatsuki-Horimoto K, Suzuki Y, Kawaoka Y. Clinical Efficacy of Imdevimab/Casirivimab for Persistent Omicron SARS-CoV-2 Infection in Patients with Hematological Malignancies. Intern Med. https://doi.org/10.2169/internalmedicine.2900-23 (2024)

21. Hiraizumi M, Akashi T, Murasaki K, Kishida H, Kumanomidou T, Torimoto N, Nureki O, Miyaguchi I. Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat Struct Mol Biol. 31(1):159-169. https://doi.org/10.1038/s41594-023-01134-0 (2024)

2023

1. Uraki R, Kiso M, Iwatsuki-Horimoto K, Yamayoshi S, Ito M, Chiba S, Sakai-Tagawa Y, Imai M, Kashima Y, Koga M, Fuwa N, Okumura N, Hojo M, Iwamoto N, Kato H, Nakajima H, Ohmagari N, Yotsuyanagi H, Suzuki Y, Kawaoka Y. Characterization of a SARS-CoV-2 EG.5.1 clinical isolate in vitro and in vivo. Cell Rep. 42(12):113580. https://doi.org/10.1016/j.celrep.2023.113580 (2023)

論文解説　新型コロナウイルス・オミクロン株EG.5.1系統は、 ハムスターで初期のオミクロン系統よりも伝播しやすい

2. Yamanouchi D, Kasuya G, Nakajo K, Kise Y, Nureki O. Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex. Mol Cell. 83(24):4555-4569.e4. https://doi.org/10.1016/j.molcel.2023.11.005 (2023)

3. Safari C, Ghosh S, Andersson R, Johannesson J, Bath P, Uwangue O, Dahl P, Zoric D, Sandelin E, Vallejos A, Nango E, Tanaka R, Bosman R, Borjesson P, Dunevall E, Hammarin G, Ortolani G, Panman M, Tanaka T, Yamashita A, Arima T, Sugahara M, Suzuki M, Masuda T, Takeda H, Yamagiwa R, Oda K, Fukuda M, Tosha T, Naitow H, Owada S, Tono K, Nureki O, Iwata S, Neutze R, Branden G. Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase. Sci Adv. 9(49):eadh4179. https://doi.org/10.1126/sciadv.adh4179 (2023)

4. Yamayoshi S, Ito M, Iwatsuki-Horimoto K, Yasuhara A, Okuda M, Hamabata T, Murakami J, Duong C, Yamamoto T, Kuroda Y, Maeda K, Kawaoka Y. Seroprevalence of SARS-CoV-2 antibodies in dogs and cats during the early and mid-pandemic periods in Japan. One Health. 17:100588. https://doi.org/10.1016/j.onehlt.2023.100588 (2023)

5. Hiramoto T, Inaba H, Baatartsogt N, Kashiwakura Y, Hayakawa M, Kamoshita N, Nishimasu H, Nureki O, Kinai E, Ohmori T. Genome editing of patient-derived iPSCs identifies a deep intronic variant causing aberrant splicing in hemophilia A. Blood Adv. 7(22):7017-7027. https://doi.org/10.1182/bloodadvances.2023010838 (2023)

6. Kingstad-Bakke B, Cleven T, Bussan H, Yount BL,Jr, Uraki R, Iwatsuki-Horimoto K, Koga M, Yamamoto S, Yotsuyanagi H, Park H, Mishra JS, Kumar S, Baric RS, Halfmann PJ, Kawaoka Y, Suresh M. Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine. JCI Insight. 8(22):e172510. doi: 10.1172/jci.insight.172510. https://doi.org/10.1172/jci.insight.172510 (2023)

7. Iwatsuki-Horimoto K, Ito M, Okuda-Hamabata M, Takagi H, Imai M, Kawaoka Y. Cardiomyopathy Does Not Exacerbate the Severity of Pneumonia Caused by a SARS-CoV-2 Delta Variant in the J2N-k Hamster Model. Viruses. 15(12):2280. doi: 10.3390/v15122280. https://doi.org/10.3390/v15122280 (2023)

8. Kuroda M, Halfmann PJ, Thackray LB, Diamond MS, Feldmann H, Marzi A, Kawaoka Y. An Antiviral Role for TRIM14 in Ebola Virus Infection. J Infect Dis. 228:S514-S521. https://doi.org/10.1093/infdis/jiad325 (2023a)

9. Halfmann PJ, Borisevich V, Levine CB, Mire CE, Fenton KA, Geisbert TW, Kawaoka Y, Cross RW. The Mucin-Like Domain of the Ebola Glycoprotein Does Not Impact Virulence or Pathogenicity in Ferrets. J Infect Dis. 228:S587-S593. https://doi.org/10.1093/infdis/jiad240 (2023)

10. Kuroda M, Halfmann PJ, Kawaoka Y. Ebola Virus Infection Induces HCAR2 Expression Leading to Cell Death. J Infect Dis. 228:S508-S513. https://doi.org/10.1093/infdis/jiad344 (2023b)

11. Kobayashi D, Kai I, Faizah AN, Moi ML, Tajima S, Takasaki T, Sasaki T, Isawa H. Comparative analysis of the susceptibility of Aedes aegypti and Japanese Aedes albopictus to all dengue virus serotypes. Trop Med Health. 51(1):61-5. https://doi.org/10.1186/s41182-023-00553-5 (2023)

12. Maemura T, Guan L, Gu C, Eisfeld A, Biswas A, Halfmann P, Neumann G, Kawaoka Y. Characterization of highly pathogenic clade 2.3.4.4b H5N1 mink influenza viruses. EBioMedicine. 97:104827. https://doi.org/10.1016/j.ebiom.2023.104827 (2023)

論文解説　ミンク由来高病原性H5N1鳥インフルエンザウイルスの性状解析

13. Ota M, Nakano M, Nagafuchi Y, Kobayashi S, Hatano H, Yoshida R, Akutsu Y, Itamiya T, Ban N, Tsuchida Y, Shoda H, Yamamoto K, Ishigaki K, Okamura T, Fujio K. Multimodal repertoire analysis unveils B cell biology in immune-mediated diseases. Ann Rheum Dis. 82(11):1455-1463. https://doi.org/10.1136/ard-2023-224421 (2023)

14. Uriu K, Ito J, Kosugi Y, Tanaka YL, Mugita Y, Guo Z, Hinay AAJ, Putri O, Kim Y, Shimizu R, Begum MM, Jonathan M, Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito A, Ikeda T, Sato K. Transmissibility, infectivity, and immune evasion of the SARS-CoV-2 BA.2.86 variant. Lancet Infect Dis. 23(11):e460-e461. https://doi.org/10.1016/S1473-3099(23)00575-3 (2023)

論文解説　SARS-CoV-2オミクロンBA.2.86株の 伝播力、感染性および免疫抵抗性

15. Dzau V, Swaminathan S, Baker C, Bright RA, Castillo J, Chuan TC, Draghia-Akli R, Eardley-Patel R, Gao GF, Ishii K, Tebeje YK, Lambe T, Machingaidze S, Rottingen J, Shaligram U, Simao M, Swarup R, Toussaint J, Wairagkar NS. The 100 Days Mission: how a new medical-countermeasures network can deliver equity and innovation. Lancet. 402(10412):1507-1510. https://doi.org/10.1016/S0140-6736(23)01775-0 (2023)

16. Hino T, Omura SN, Nakagawa R, Togashi T, Takeda SN, Hiramoto T, Tasaka S, Hirano H, Tokuyama T, Uosaki H, Ishiguro S, Kagieva M, Yamano H, Ozaki Y, Motooka D, Mori H, Kirita Y, Kise Y, Itoh Y, Matoba S, Aburatani H, Yachie N, Karvelis T, Siksnys V, Ohmori T, Hoshino A, Nureki O. An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis. Cell. 186(22):4920-4935.e23. https://doi.org/10.1016/j.cell.2023.08.031 (2023)

17. Shoda H, Natsumoto B, Fujio K. Investigation of immune-related diseases using patient-derived induced pluripotent stem cells. Inflamm Regen. 43(1):51-4. https://doi.org/10.1186/s41232-023-00303-4 (2023)

18. Wang Y, Morishima T, Sezaki M, Sato R, Nakato G, Fukuda S, Kobiyama K, Ishii KJ, Li Y, Takizawa H. Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals. EMBO Rep. :e57485. https://doi.org/10.15252/embr.202357485 (2023)

19. Koda T, Natsumoto B, Shoda H, Fujio K. Nonepisodic Angioedema with Eosinophilia Following Receipt of the BNT162b2 mRNA COVID-19 Vaccine. Intern Med. 62(20):3063-3067. https://doi.org/10.2169/internalmedicine.1788-23 (2023)

20. Wilks SH, Mühlemann B, Shen X, Türeli S, LeGresley EB, Netzl A, Caniza MA, Chacaltana-Huarcaya J, Corman VM, Daniell X, Datto MB, Dawood FS, Denny TN, Drosten C, Fouchier RAM, Garcia PJ, Halfmann PJ, Jassem A, Jeworowski LM, Jones TC, Kawaoka Y, Krammer F, McDanal C, Pajon R, Simon V, Stockwell MS, Tang H, van Bakel H, Veguilla V, Webby R, Montefiori DC, Smith DJ. Mapping SARS-CoV-2 antigenic relationships and serological responses. Science. 382(6666):eadj0070. https://doi.org/10.1126/science.adj0070 (2023)

21. Uraki R, Ito M, Kiso M, Yamayoshi S, Iwatsuki-Horimoto K, Sakai-Tagawa Y, Imai M, Koga M, Yamamoto S, Adachi E, Saito M, Tsutsumi T, Otani A, Fukushi S, Watanabe S, Suzuki T, Kikuchi T, Yotsuyanagi H, Maeda K, Kawaoka Y. Antiviral efficacy against and replicative fitness of an XBB.1.9.1 clinical isolate. iScience. 26(11):108147. https://doi.org/10.1016/j.isci.2023.108147 (2023)

論文解説　新型コロナウイルス・オミクロン株のXBB.1.9.1系統は XBB.1.5系統と類似の性状を持つ

22. Kikuchi C, Antonopoulos A, Wang S, Maemura T, Karamanska R, Lee C, Thompson AJ, Dell A, Kawaoka Y, Haslam SM, Paulson JC. Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines. Nat Commun. 14(1):6178-0. https://doi.org/10.1038/s41467-023-41908-0 (2023)

23. Scarno G, Mazej J, Laffranchi M, Di Censo C, Mattiola I, Candelotti AM, Pietropaolo G, Stabile H, Fionda C, Peruzzi G, Brooks SR, Tsai WL, Mikami Y, Bernardini G, Gismondi A, Sozzani S, Di Santo JP, Vosshenrich CAJ, Diefenbach A, Gadina M, Santoni A, Sciume G. Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation. Proc Natl Acad Sci U S A. 120(40):e2306761120. https://doi.org/10.1073/pnas.2306761120 (2023)

24. Katsikis PD, Ishii KJ, Schliehe C. Challenges in developing personalized neoantigen cancer vaccines. Nat Rev Immunol. https://doi.org/10.1038/s41577-023-00937-y (2023)

25. Kaku Y, Kosugi Y, Uriu K, Ito J, Hinay AAJ, Kuramochi J, Sadamasu K, Yoshimura K, Asakura H, Nagashima M, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K. Antiviral efficacy of the SARS-CoV-2 XBB breakthrough infection sera against omicron subvariants including EG.5. Lancet Infect Dis. 23(10):e395-e396. https://doi.org/10.1016/S1473-3099(23)00553-4 (2023)

論文解説　SARS-CoV-2 XBBブレイクスルー感染者血清の、 EG.5を含むオミクロン変異株への抗ウイルス作用の解析

26. Kashima Y, Mizutani T, Okimoto Y, Maeda M, Musashino K, Nishide R, Matsukura A, Nagase J, Suzuki Y. Evolution of the viral genomes of SARS-CoV-2 in association with the changes in local condition: a genomic epidemiological study of a suburban city of Japan. DNA Res. 30(5):dsad020. doi: 10.1093/dnares/dsad020. https://doi.org/10.1093/dnares/dsad020 (2023)

27. Hou YJ, Chiba S, Leist SR, Meganck RM, Martinez DR, Schafer A, Catanzaro NJ, Sontake V, West A, Edwards CE, Yount B, Lee RE, Gallant SC, Zost SJ, Powers J, Adams L, Kong EF, Mattocks M, Tata A, Randell SH, Tata PR, Halfmann P, Crowe JE,Jr, Kawaoka Y, Baric RS. Host range, transmissibility and antigenicity of a pangolin coronavirus. Nat Microbiol. 8(10):1820-1833. https://doi.org/10.1038/s41564-023-01476-x (2023)

28. Zhang Z, Shibata T, Fujimura A, Kitaura J, Miyake K, Ohto U, Shimizu T. Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature. 622(7981):188-194. https://doi.org/10.1038/s41586-023-06532-4 (2023)

29. Shihoya W, Sano FK, Nureki O. Structural insights into endothelin receptor signalling. J Biochem. 174(4):317-325. https://doi.org/10.1093/jb/mvad055 (2023)

30. Zhuo S, Noda N, Hioki K, Jin S, Hayashi T, Hiraga K, Momose H, Li W, Zhao L, Mizukami T, Ishii KJ, Li Y, Uesugi M. Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile. J Med Chem. 66(18):13266-13279. https://doi.org/10.1021/acs.jmedchem.3c01252 (2023)

31. Dott T, Culina S, Chemali R, Mansour CA, Dubois F, Jagla B, Doisne JM, Rogge L, Huetz F, Jonsson F, Commere P, Di Santo J, Terrier B, Quintana-Murci L, Duffy D, Hasan M, Milieu IC. Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies. Cytometry A. https://doi.org/10.1002/cyto.a.24801 (2023)

32. Yao L, Chemaitelly H, Goldman E, Gudina EK, Khalil A, Ahmed R, James AB, Roca A, Fallah MP, Macnab A, Cho WC, Eikelboom J, Qamar FN, Kremsner P, Oliu-Barton M, Sisa I, Tadesse BT, Marks F, Wang L, Kim JH, Meng X, Wang Y, Fly AD, Wang C, Day SW, Howard SC, Graff JC, Maida M, Ray K, Franco-Paredes C, Mashe T, Ngongo N, Kaseya J, Ndembi N, Hu Y, Bottazzi ME, Hotez PJ, Ishii KJ, Wang G, Sun D, Aleya L, Gu W. Time to establish an international vaccine candidate pool for potential highly infectious respiratory disease: a community's view. EClinicalMedicine. 64:102222. https://doi.org/10.1016/j.eclinm.2023.102222 (2023)

33. Chiba S, Halfmann PJ, Iida S, Hirata Y, Sato Y, Kuroda M, Armbrust T, Spyra S, Suzuki T, Kawaoka Y. Recombinant spike protein vaccines coupled with adjuvants that have different modes of action induce protective immunity against SARS-CoV-2. Vaccine. 41(41):6025-6035. https://doi.org/10.1016/j.vaccine.2023.08.054 (2023)

34. Fujita S, Kosugi Y, Kimura I, Tokunaga K, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ito J, Sato K. Determination of the factors responsible for the tropism of SARS-CoV-2-related bat coronaviruses to Rhinolophus bat ACE2. J Virol. :e0099023. https://doi.org/10.1128/jvi.00990-23 (2023)

35. Komagamine M, Komatsu N, Ling R, Okamoto K, Tianshu S, Matsuda K, Takeuchi T, Kaneko Y, Takayanagi H. Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss. Inflamm Regen. 43(1):44-3. https://doi.org/10.1186/s41232-023-00293-3 (2023)

36. Inoue M, Nagafuchi Y, Ota M, Tsuchiya H, Tateishi S, Kanda H, Fujio K. Carriers of HLA-DRB1*04:05 have a better clinical response to abatacept in rheumatoid arthritis. Sci Rep. 13(1):15250-6. https://doi.org/10.1038/s41598-023-42324-6 (2023)

37. Shibata T, Sato R, Taoka M, Saitoh S, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. J Exp Med. 220(9):e20230054. doi: 10.1084/jem.20230054. Epub 2023 Jul 18. https://doi.org/10.1084/jem.20230054 (2023)

38. Kimura A, Takagi T, Thamamongood T, Sakamoto S, Ito T, Seki I, Okamoto M, Aono H, Serada S, Naka T, Imataka H, Miyake K, Ueda T, Miyanokoshi M, Wakasugi K, Iwamoto N, Ohmagari N, Iguchi T, Nitta T, Takayanagi H, Yamashita H, Kaneko H, Tsuchiya H, Fujio K, Handa H, Suzuki H. Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4. Ann Rheum Dis. 82(9):1153-1161. https://doi.org/10.1136/ard-2023-224055 (2023)

39. Fukui A, Maruzuru Y, Ohno S, Nobe M, Iwata S, Takeshima K, Koyanagi N, Kato A, Kitazume S, Yamaguchi Y, Kawaguchi Y. Dual impacts of a glycan shield on the envelope glycoprotein B of HSV-1: evasion from human antibodies in vivo and neurovirulence. mBio. 14(4):e0099223-23. Epub 2023 Jun 27. https://doi.org/10.1128/mbio.00992-23 (2023)

40. Chiba S, Kong H, Neumann G, Kawaoka Y. Influenza H3 hemagglutinin vaccine with scrambled immunodominant epitopes elicits antibodies directed toward immunosubdominant head epitopes. mBio. 14(4):e0062223-23. Epub 2023 Jul 19. https://doi.org/10.1128/mbio.00622-23 (2023)

論文解説　インフルエンザウイルスHAの変異し難い部位をねらう　ワクチン抗原のデザイン　 ―ユニバーサルワクチンの新規ストラテジー―

41. Abeygoonawardena H, Wijesinghe N, Navaratne V, Balasuriya A, Nguyen TTN, Moi ML, De Silva AD. Serological Evidence of Zika virus Circulation with Dengue and Chikungunya Infections in Sri Lanka from 2017. J Glob Infect Dis. 15(3):113-120. https://doi.org/10.4103/jgid.jgid_195_22 (2023)

42. Mise-Omata S, Ando M, Srirat T, Nakagawara K, Hayakawa T, Iizuka-Koga M, Nishimasu H, Nureki O, Ito M, Yoshimura A. SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine. Cell Rep. 42(8):112940. https://doi.org/10.1016/j.celrep.2023.112940 (2023)

43. Thaller AL, Jonsson F, Fiquet O, Marie S, Doisne J, Girelli-Zubani G, Eri T, Fernandes P, Tatirovsky E, Langa-Vives F, Bruhns P, Strick-Marchand H, Di Santo JP. A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR(+) cells during antibody-mediated immune responses. Eur J Immunol. :e2350454. https://doi.org/10.1002/eji.202350454 (2023)

44. Ishimura R, Ito S, Mao G, Komatsu-Hirota S, Inada T, Noda NN, Komatsu M. Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control. Sci Adv. 9(33):eadh3635. https://doi.org/10.1126/sciadv.adh3635 (2023)

45. Guan L, Ping J, Lopes TJS, Fan S, Presler R, Neumann G, Kawaoka Y. Development of an Enhanced High-Yield Influenza Vaccine Backbone in Embryonated Chicken Eggs. Vaccines (Basel). 11(8):1364. doi: 10.3390/vaccines11081364. https://doi.org/10.3390/vaccines11081364 (2023)

46. Yan M, Tsukasaki M, Muro R, Ando Y, Nakamura K, Komatsu N, Nitta T, Okamura T, Okamoto K, Takayanagi H. Identification of an intronic enhancer regulating RANKL expression in osteocytic cells. Bone Res. 11(1):43-6. https://doi.org/10.1038/s41413-023-00277-6 (2023)

47. Tomoda E, Nagao A, Shirai Y, Asano K, Suzuki T, Battersby BJ, Suzuki T. Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases. Nucleic Acids Res. 51(14):7563-7579. https://doi.org/10.1093/nar/gkad139 (2023)

48. Takashita E, Fujisaki S, Morita H, Nagata S, Miura H, Nagashima M, Watanabe S, Takeda M, Kawaoka Y, Hasegawa H. Assessment of the frequency of SARS-CoV-2 Omicron variant escape from RNA-dependent RNA polymerase inhibitors and 3C-like protease inhibitors. Antiviral Res. 216:105671. https://doi.org/10.1016/j.antiviral.2023.105671 (2023)

49. Omura SN, Nakagawa R, Südfeld C, Villegas Warren R, Wu WY, Hirano H, Laffeber C, Kusakizako T, Kise Y, Lebbink JHG, Itoh Y, van der Oost J, Nureki O. Mechanistic and evolutionary insights into a type V-M CRISPR-Cas effector enzyme. Nat Struct Mol Biol. 30(8):1172-1182. https://doi.org/10.1038/s41594-023-01042-3 (2023)

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51. Guan L, Babujee L, Browning VL, Presler R, Pattinson D, Nguyen HLK, Hoang VMP, Le MQ, van Bakel H, Neumann G, Kawaoka Y. Continued Circulation of Highly Pathogenic H5 Influenza Viruses in Vietnamese Live Bird Markets in 2018-2021. Viruses. 15(7):1596. doi: 10.3390/v15071596. https://doi.org/10.3390/v15071596 (2023)

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53. Kiso M, Yamayoshi S, Iida S, Furusawa Y, Hirata Y, Uraki R, Imai M, Suzuki T, Kawaoka Y. In vitro and in vivo characterization of SARS-CoV-2 resistance to ensitrelvir. Nat Commun. 14(1):4231-1. https://doi.org/10.1038/s41467-023-40018-1 (2023)

論文解説　ゾコーバ耐性新型コロナウイルスの性状解析

54. Li J, Chen Z, Kim G, Luo J, Hori S, Wu C. Cathepsin W restrains peripheral regulatory T cells for mucosal immune quiescence. Sci Adv. 9(28):eadf3924. https://doi.org/10.1126/sciadv.adf3924 (2023)

55. Ishizaka A, Koga M, Mizutani T, Uraki R, Yamayoshi S, Iwatsuki-Horimoto K, Yamamoto S, Imai M, Tsutsumi T, Suzuki Y, Kawaoka Y, Yotsuyanagi H. Research article antibody induction and immune response in nasal cavity by third dose of SARS-CoV-2 mRNA vaccination. Virol J. 20(1):146-z. https://doi.org/10.1186/s12985-023-02113-z (2023)

56. Kiso M, Yamayoshi S, Kawaoka Y. Efficacy of favipiravir against influenza virus resistant to both baloxavir and neuraminidase inhibitors. J Antimicrob Chemother. 78(7):1649-1657. https://doi.org/10.1093/jac/dkad145 (2023)

57. Kiso M, Furusawa Y, Uraki R, Imai M, Yamayoshi S, Kawaoka Y. In vitro and in vivo characterization of SARS-CoV-2 strains resistant to nirmatrelvir. Nat Commun. 14(1):3952-x. https://doi.org/10.1038/s41467-023-39704-x (2023)

論文解説　ニルマトレルビル耐性新型コロナウイルスの性状解析

58. Muramoto Y, Takahashi S, Halfmann PJ, Gotoh S, Noda T, Kawaoka Y. Replicative capacity of SARS-CoV-2 omicron variants BA.5 and BQ.1.1 at elevated temperatures. Lancet Microbe. 4(7):e486-3. Epub 2023 Apr 24. https://doi.org/10.1016/S2666-5247(23)00100-3 (2023)

論文解説　新型コロナウイルス・オミクロン株のBA.5系統およびBQ.1.1系統が、高温で増殖しづらいことを解明

59. Nagai M, Moriyama M, Ishii C, Mori H, Watanabe H, Nakahara T, Yamada T, Ishikawa D, Ishikawa T, Hirayama A, Kimura I, Nagahara A, Naito T, Fukuda S, Ichinohe T. High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection. Nat Commun. 14(1):3863. https://doi.org/10.1038/s41467-023-39569-0 (2023) 

論文解説　発熱がウイルス性肺炎の重症化を抑制するメカニズムを解明 ――重症化の抑制には38℃以上の体温で活性化した腸内細菌叢が必要だった――

60. Yamamoto S, Yamayoshi S, Ito M, Sakai-Tagawa Y, Nakachi I, Baba R, Kamimoto S, Ogura T, Hagiwara S, Kato H, Nakajima H, Uwamino Y, Yagi K, Sugaya N, Nagai H, Saito M, Adachi E, Koga M, Tsutsumi T, Duong C, Okuda M, Murakami J, Furusawa Y, Ujie M, Iwatsuki-Horimoto K, Yotsuyanagi H, Kawaoka Y. Differences among epitopes recognized by neutralizing antibodies induced by SARS-CoV-2 infection or COVID-19 vaccination. iScience. 26(7):107208. https://doi.org/10.1016/j.isci.2023.107208 (2023)

61. Halfmann PJ, Uraki R, Kuroda M, Iwatsuki-Horimoto K, Yamayoshi S, Ito M, Kawaoka Y. Transmission and re-infection of Omicron variant XBB.1.5 in hamsters. eBioMedicine. 93:104677. https://doi.org/10.1016/j.ebiom.2023.104677 (2023) 

論文解説　新型コロナウイルス・オミクロン株XBB.1.5系統は、 ハムスターで初期のオミクロン系統よりも伝播しやすい

62. Takeshita M, Fukuyama H, Kamada K, Matsumoto T, Makino-Okamura C, Lin Q, Sakuma M, Kawahara E, Yamazaki I, Uchikubo-Kamo T, Tomabechi Y, Hanada K, Hisano T, Moriyama S, Takahashi Y, Ito M, Imai M, Maemura T, Furusawa Y, Yamayoshi S, Kawaoka Y, Shirouzu M, Ishii M, Saya H, Kondo Y, Kaneko Y, Suzuki K, Fukunaga K, Takeuchi T, Keio DP. Potent neutralizing broad-spectrum antibody against SARS-CoV-2 generated from dual-antigen-specific B cells from convalescents. iScience. 26(6):106955. https://doi.org/10.1016/j.isci.2023.106955 (2023)

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67. Tamura D, Kawaoka Y. Omicron proliferation in the nasal cavity may explain its high infectivity. J Infect. 86(6):584-587. https://doi.org/10.1016/j.jinf.2023.03.006 (2023)

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論文解説　SARS-CoV-2オミクロンXBB.1.16株の ウイルス学的特性の解明

69. Saito Y, Takahashi T, Hiramatsu K, Serada S, Fujimoto M, Ohkawara T, Sugase T, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Nakajima K, Yamasaki M, Ishii KJ, Eguchi H, Doki Y, Naka T. Nano-particulate Toll-like Receptor 9 Agonist Potentiates the Antitumor Activity of Anti-Glypican-1 Antibody. Anticancer Res. 43(6):2425-2432. https://doi.org/10.21873/anticanres.16410 (2023)

70. Fujikawa D, Nakamura T, Yoshioka D, Li Z, Moriizumi H, Taguchi M, Tokai-Nishizumi N, Kozuka-Hata H, Oyama M, Takekawa M. Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases. Curr Biol. 33(10):1967-1981.e8. https://doi.org/10.1016/j.cub.2023.04.012 (2023)

論文解説　液-液相分離体「ストレス顆粒」形成による ストレス防御および癌進展機構の解明 ――ストレス環境下で細胞がアポトーシスを回避する新たな仕組みを発見――

71. Nakamura Y, Moi ML, Shiina T, Shin-I T, Suzuki R. Idiotope-Driven T-Cell/B-Cell Collaboration-Based T-Cell Epitope Prediction Using B-Cell Receptor Repertoire Sequences in Infectious Diseases. Viruses-Basel. 15(5):1186. https://doi.org/10.3390/v15051186 (2023)

72. Nagao A, Nakanishi Y, Yamaguchi Y, Mishina Y, Karoji M, Toya T, Fujita T, Iwasaki S, Miyauchi K, Sakaguchi Y, Suzuki T. Quality control of protein synthesis in the early elongation stage. Nat Commun. 14(1):2704-5. https://doi.org/10.1038/s41467-023-38077-5 (2023)

73. Shibata K, Oda K, Nishizawa T, Hazama Y, Ono R, Takaramoto S, Bagherzadeh R, Yawo H, Nureki O, Inoue K, Akiyama H. Twisting and Protonation of Retinal Chromophore Regulate Channel Gating of Channelrhodopsin C1C2. J Am Chem Soc. 145(19):10779-10789. https://doi.org/10.1021/jacs.3c01879 (2023)

74. Tamura T, Ito J, Uriu K, Zahradnik J, Kida I, Anraku Y, Nasser H, Shofa M, Oda Y, Lytras S, Nao N, Itakura Y, Deguchi S, Suzuki R, Wang L, Begum MM, Kita S, Yajima H, Sasaki J, Sasaki-Tabata K, Shimizu R, Tsuda M, Kosugi Y, Fujita S, Pan L, Sauter D, Yoshimatsu K, Suzuki S, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Schreiber G, Maenaka K, Genotype to Phenotype Japan (G2P-Japan) Consortium, Hashiguchi T, Ikeda T, Fukuhara T, Saito A, Tanaka S, Matsuno K, Takayama K, Sato K. Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants. Nat Commun. 14(1):2800-3. https://doi.org/10.1038/s41467-023-38435-3 (2023)

論文解説　オミクロンXBB株の進化経路とウイルス学的特性の解明 ――遺伝子組換えによる更なる免疫逃避能力の獲得――

75. Ikeuchi K, Ivic N, Buschauer R, Cheng J, Froehlich T, Matsuo Y, Berninghausen O, Inada T, Becker T, Beckmann R. Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. Nat Commun. 14(1):2730. https://doi.org/10.1038/s41467-023-38161-w (2023)

76. Ito J, Suzuki R, Uriu K, Itakura Y, Zahradnik J, Kimura KT, Deguchi S, Wang L, Lytras S, Tamura T, Kida I, Nasser H, Shofa M, Begum MM, Tsuda M, Oda Y, Suzuki T, Sasaki J, Sasaki-Tabata K, Fujita S, Yoshimatsu K, Ito H, Nao N, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Kuramochi J, Schreiber G, Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito A, Matsuno K, Takayama K, Hashiguchi T, Tanaka S, Fukuhara T, Ikeda T, Sato K. Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant. Nat Commun. 14(1):2671-z. https://doi.org/10.1038/s41467-023-38188-z (2023)

論文解説　SARS-CoV-2オミクロン株の進化パターンの一端を解明 ――スパイクタンパク質の収斂進化が適応度の高い変異株の出現に繋がる――

77. Uraki R, Ito M, Kiso M, Yamayoshi S, Iwatsuki-Horimoto K, Sakai-Tagawa Y, Imai M, Koga M, Yamamoto S, Adachi E, Saito M, Tsutsumi T, Otani A, Kashima Y, Kikuchi T, Theiler J, Yotsuyanagi H, Suzuki Y, Korber B, Kawaoka Y. Efficacy of antivirals and mRNA vaccination against an XBF clinical isolate. Lancet Reg Health West Pac. 34:100777. https://doi.org/10.1016/j.lanwpc.2023.100777 (2023) 

論文解説　BA.4/5株対応2価mRNAワクチン接種で、 新型コロナウイルス・オミクロン株XBF系統に対する 中和活性は増強される

78. Uraki R, Ito M, Kiso M, Yamayoshi S, Iwatsuki-Horimoto K, Sakai-Tagawa Y, Furusawa Y, Imai M, Koga M, Yamamoto S, Adachi E, Saito M, Tsutsumi T, Otani A, Kashima Y, Kikuchi T, Yotsuyanagi H, Suzuki Y, Kawaoka Y. Efficacy of antivirals and bivalent mRNA vaccines against SARS-CoV-2 isolate CH.1.1. Lancet Infect Dis. 23(5):525-526. https://doi.org/10.1016/S1473-3099(23)00132-9 (2023)

論文解説　新型コロナウイルス・オミクロン株のCH.1.1系統に対する 治療薬と2価ワクチンの効果を検証

79. Furusawa Y, Kiso M, Iida S, Uraki R, Hirata Y, Imai M, Suzuki T, Yamayoshi S, Kawaoka Y. In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamsters. EBioMedicine. 91:104561. https://doi.org/10.1016/j.ebiom.2023.104561 (2023)

論文解説　新型コロナウイルス・デルタ変異株の Spike-P681RおよびD950N変異の機能解析

80. Amada K, Hijiya N, Ikarimoto S, Yanagihara K, Hanada T, Hidano S, Kurogi S, Tsukamoto Y, Nakada C, Kinoshita K, Hirashita Y, Uchida T, Shin T, Yada K, Hirashita T, Kobayashi T, Murakami K, Inomata M, Shirao K, Aoki M, Takekawa M, Moriyama M. Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor. Cancer Sci. 114(5):2189-2202. https://doi.org/10.1111/cas.15735 (2023)

81. Sakai-Tagawa Y, Yamayoshi S, Halfmann PJ, Wilson N, Bobholz M, Vuyk WC, Wei W, Ries H, O'Connor DH, Friedrich TC, Sordillo EM, van Bakel H, Simon V, Kawaoka Y. Sensitivity of rapid antigen tests for Omicron subvariants of SARS-CoV-2. J Med Virol. 95(5):e28788. https://doi.org/10.1002/jmv.28788 (2023)

82. Chowdhury SI, Inui M, Yamazaki T, Tomono S, Takagi H, Biswas M, Saitoh S, Miyake K, Akashi-Takamura S. The anti-TLR4 monoclonal antibody Sa15-21 enhances inflammatory cytokine production in LPS-stimulated macrophages. FEBS Lett. 597(9):1246-1260. https://doi.org/10.1002/1873-3468.14619 (2023)

83. Otsuka Saito K, Fujita F, Toriyama M, Utami RA, Guo Z, Murakami M, Kato H, Suzuki Y, Okada F, Tominaga M, Ishii KJ. Roles of TRPM4 in immune responses in keratinocytes and identification of a novel TRPM4-activating agent. Biochem Biophys Res Commun. 654:1-9. https://doi.org/10.1016/j.bbrc.2023.02.062 (2023)

84. Guan L, Zhong G, Fan S, Plisch EM, Presler R, Gu C, Babujee L, Pattinson D, Le Khanh Nguyen H, Hoang VMP, Le MQ, van Bakel H, Neumann G, Kawaoka Y. Highly Pathogenic H5 Influenza Viruses Isolated between 2016 and 2017 in Vietnamese Live Bird Markets. Viruses-Basel. 15(5):1093. https://doi.org/10.3390/v15051093 (2023)

85. Ekemen S, Comunoglu C, Kayhan CK, Bilir E, Cavusoglu I, Etiler N, Bilgi S, Ince U, Coban C, Erden HF. Endometrial Staining of CD56 (Uterine Natural Killer), BCL-6, and CD138 (Plasma Cells) Improve Diagnosis and Clinical Pregnancy Outcomes in Unexplained Infertility and Recurrent IVF Failures: Standardization of Diagnosis with Digital Pathology. Diagnostics. 13(9):1557. https://doi.org/10.3390/diagnostics13091557 (2023)

86. Sano F, Akasaka H, Shihoya W, Nureki O. Cryo-EM structure of the endothelin-1-ET(B)-G(i) complex. Elife. 12:10.7554/eLife.85821. https://doi.org/10.7554/eLife.85821 (2023)

87. Hiramoto T, Kashiwakura Y, Hayakawa M, Baatartsogt N, Kamoshita N, Abe T, Inaba H, Nishimasu H, Uosaki H, Hanazono Y, Nureki O, Ohmori T. PAM-flexible Cas9-mediated base editing of a hemophilia B mutation in induced pluripotent stem cells. Commun Med (Lond). 3(1):56-w. https://doi.org/10.1038/s43856-023-00286-w (2023)

88. Changrob S, Halfmann PJ, Liu H, Torres JL, McGrath JJC, Ozorowski G, Li L, Wilbanks GD, Kuroda M, Maemura T, Huang M, Zheng N, Turner HL, Erickson SA, Fu Y, Yasuhara A, Singh G, Monahan B, Mauldin J, Srivastava K, Simon V, Krammer F, Sather DN, Ward AB, Wilson IA, Kawaoka Y, Wilson PC. Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants. J Clin Invest. 133(8):e166844. doi: 10.1172/JCI166844. https://doi.org/10.1172/JCI166844 (2023)

89. Hill-Batorski L, Hatta Y, Moser MJ, Sarawar S, Neumann G, Kawaoka Y, Bilsel P. Quadrivalent Formulation of Intranasal Influenza Vaccine M2SR (M2-Deficient Single Replication) Protects against Drifted Influenza A and B Virus Challenge. Vaccines (Basel). 11(4):798. doi: 10.3390/vaccines11040798. https://doi.org/10.3390/vaccines11040798 (2023)

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論文解説　新型コロナウイルス・オミクロン株のXBB.1.5系統に対する 治療薬とワクチンの効果を検証

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News Release　Study reveals the 3D structure of a protein involved in genome editing

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93. Saitoh H, Sakai-Tagawa Y, Nagasawa S, Torimitsu S, Kubota K, Hirata Y, Iwatsuki-Horimoto K, Motomura A, Ishii N, Okaba K, Horioka K, Abe H, Ikemura M, Rokutan H, Hinata M, Iwasaki A, Yasunaga Y, Nakajima M, Yamaguchi R, Tsuneya S, Kira K, Kobayashi S, Inokuchi G, Chiba F, Hoshioka Y, Mori A, Yamamoto I, Nakagawa K, Katano H, Iida S, Suzuki T, Akitomi S, Hasegawa I, Ushiku T, Yajima D, Iwase H, Makino Y, Kawaoka Y. High titers of infectious SARS-CoV-2 in corpses of patients with COVID-19. Int J Infect Dis. 129:103-109. https://doi.org/10.1016/j.ijid.2023.01.046 (2023)

94. Sun X, Hosomi K, Shimoyama A, Yoshii K, Lan H, Wang Y, Yamaura H, Nagatake T, Ishii KJ, Akira S, Kiyono H, Fukase K, Kunisawa J. TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells. Int Immunopharmacol. 117:109852. https://doi.org/10.1016/j.intimp.2023.109852 (2023)

95. Ito D, Ito H, Ando T, Sakai Y, Ideta T, Ishii KJ, Ishikawa T, Shimizu M. Spermidine enhances the efficacy of adjuvant in HBV vaccination in mice. Hepatol Commun. 7(4):e0104. doi: 10.1097/HC9.0000000000000104. eCollection 2023 Apr 1. https://doi.org/10.1097/HC9.0000000000000104 (2023)

96. Uraki R, Iida S, Halfmann PJ, Yamayoshi S, Hirata Y, Iwatsuki-Horimoto K, Kiso M, Ito M, Furusawa Y, Ueki H, Sakai-Tagawa Y, Kuroda M, Maemura T, Kim T, Mine S, Iwamoto N, Li R, Liu Y, Larson D, Fukushi S, Watanabe S, Maeda K, Wang Z, Ohmagari N, Theiler J, Fischer W, Korber B, Imai M, Suzuki T, Kawaoka Y. Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates. Nat Commun. 14(1):1620-x. https://doi.org/10.1038/s41467-023-37059-x (2023)

論文解説　新型コロナウイルス・オミクロン変異株のBA.2.75系統の性状解析

97. Furusawa Y, Yamayoshi S, Kawaoka Y. The accuracy of reverse genetics systems for SARS-CoV-2: Circular polymerase extension reaction versus bacterial artificial chromosome. Influenza Other Respir Viruses. 17(3):e13109. https://doi.org/10.1111/irv.13109 (2023)

98. Sukegawa S, Nureki O, Toki S, Saika H. Genome editing in rice mediated by miniature size Cas nuclease SpCas12f. Front Genome Ed. 5:1138843. https://doi.org/10.3389/fgeed.2023.1138843 (2023)

99. Tatsuma T, Nakakido M, Ichinohe T, Kuroiwa Y, Tomioka K, Liu C, Miyamae N, Onuki T, Tsumoto K, Hashimoto K, Wakihara T. Inactivation and spike protein denaturation of novel coronavirus variants by CuxO/TiO2 nano-photocatalysts. Sci Rep. 13(1) https://doi.org/10.1038/s41598-023-30690-0 (2023)

100. Petrie JG, King JP, McClure DL, Rolfes MA, Meece JK, Pattinson D, Neumann G, Kawaoka Y, Belongia EA, McLean HQ. Effectiveness of first and second COVID-19 mRNA vaccine monovalent booster doses during a period of circulation of Omicron variant sublineages: December 2021-July 2022. Influenza Other Respir Viruses. 17(3):e13104. https://doi.org/10.1111/irv.13104 (2023)

101. Uriu K, Ito J, Zahradnik J, Fujita S, Kosugi Y, Schreiber G, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K. Enhanced transmissibility, infectivity, and immune resistance of the SARS-CoV-2 omicron XBB.1.5 variant. Lancet Infect Dis. 23(3):280-281. https://doi.org/10.1016/S1473-3099(23)00051-8 (2023)

論文解説　SARS-CoV-2オミクロンXBB.1.5株のウイルス学的性状の解明

102. Fukui A, Maruzuru Y, Takeshima K, Koyanagi N, Kato A, Kawaguchi Y. Establishment of a system to quantify wild-type herpes simplex virus-induced cell-cell fusion reveals a role of N-glycosylation of HSV-1 envelope glycoprotein B in cell-cell fusion. Microbiol Immunol. 67(3):114-119. https://doi.org/10.1111/1348-0421.13050 (2023)

103. Bramer LM, Hontz RD, Eisfeld AJ, Sims AC, Kim Y, Stratton KG, Nicora CD, Gritsenko MA, Schepmoes AA, Akasaka O, Koga M, Tsutsumi T, Nakamura M, Nakachi I, Baba R, Tateno H, Suzuki S, Nakajima H, Kato H, Ishida K, Ishii M, Uwamino Y, Mitamura K, Paurus VL, Nakayasu ES, Attah IK, Letizia AG, Waters KM, Metz TO, Corson K, Kawaoka Y, Gerbasi VR, Yotsuyanagi H, Iwatsuki-Horimoto K. Multi-omics of NET formation and correlations with CNDP1, PSPB, and L-cystine levels in severe and mild COVID-19 infections. Heliyon. 9(3):e13795. https://doi.org/10.1016/j.heliyon.2023.e13795 (2023)

104. Chazan A, Das I, Fujiwara T, Murakoshi S, Rozenberg A, Molina-Marquez A, Sano FK, Tanaka T, Gomez-Villegas P, Larom S, Pushkarev A, Malakar P, Hasegawa M, Tsukamoto Y, Ishizuka T, Konno M, Nagata T, Mizuno Y, Katayama K, Abe-Yoshizumi R, Ruhman S, Inoue K, Kandori H, Leon R, Shihoya W, Yoshizawa S, Sheves M, Nureki O, Beja O. Phototrophy by antenna-containing rhodopsin pumps in aquatic environments. Nature. 615(7952):535-540. https://doi.org/10.1038/s41586-023-05774-6 (2023)

105. Kuchitsu Y, Mukai K, Uematsu R, Takaada Y, Shinojima A, Shindo R, Shoji T, Hamano S, Ogawa E, Sato R, Miyake K, Kato A, Kawaguchi Y, Nishitani-Isa M, Izawa K, Nishikomori R, Yasumi T, Suzuki T, Dohmae N, Uemura T, Barber GN, Arai H, Waguri S, Taguchi T. STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes. Nat Cell Biol. 25(3):453-466. https://doi.org/10.1038/s41556-023-01098-9 (2023)

106. Okamoto K, Takayanagi H. Effect of T cells on bone. Bone. 168:116675. https://doi.org/10.1016/j.bone.2023.116675 (2023)

107. Wijaya TJ, Yokota T, Lee S, Okano R, Kobayashi M, Someya T. Photostability Improvement of Organic Photodiodes with ZnO Electron Transport Layer. Adv Photon Res. 4(3) https://doi.org/10.1002/adpr.202200355 (2023)

108. Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori S, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H. Identification of SARS-CoV-2 M(pro) inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nat Commun. 14(1):1076-0. https://doi.org/10.1038/s41467-023-36729-0 (2023)

109. McLean HQ, Petrie JG, Hanson KE, Meece JK, Rolfes MA, Sylvester GC, Neumann G, Kawaoka Y, Belongia EA. Interim Estimates of 2022-23 Seasonal Influenza Vaccine Effectiveness - Wisconsin, October 2022-February 2023. MMWR Morb Mortal Wkly Rep. 72(8):201-205. https://doi.org/10.15585/mmwr.mm7208a1 (2023)

110. Yotsuyanagi H, Ohmagari N, Doi Y, Imamura T, Sonoyama T, Ichihashi G, Sanaki T, Tsuge Y, Uehara T, Mukae H. A phase 2/3 study of S-217622 in participants with SARS-CoV-2 infection (Phase 3 part). Medicine (Baltimore). 102(8):e33024. https://doi.org/10.1097/MD.0000000000033024 (2023)

111. Nakayama T, Azegami T, Kiso M, Imai M, Uraki R, Hayashi K, Hishikawa A, Yoshimoto N, Nakamichi R, Sugita-Nishimura E, Yoshida-Hama E, Kawaoka Y, Itoh H. Plasminogen activator inhibitor 1 is not a major causative factor for exacerbation in a mouse model of SARS-CoV-2 infection. Sci Rep. 13(1):3103-8. https://doi.org/10.1038/s41598-023-30305-8 (2023)

112. Iwatsuki-Horimoto K, Ueki H, Ito M, Nagasawa S, Hirata Y, Hashizume K, Ushiwata K, Iwase H, Makino Y, Ushiku T, Akitomi S, Imai M, Saitoh H, Kawaoka Y. SARS-CoV-2 Transmission from Virus-Infected Dead Hamsters. mSphere. 8(1):e0041122-22. Epub 2023 Jan 10. https://doi.org/10.1128/msphere.00411-22 (2023)

論文解説　SARS-CoV-2感染動物死体からのウイルス伝播

113. Yoshioka Y, Kobiyama K, Hayashi T, Onishi M, Yanagida Y, Nakagawa T, Hashimoto M, Nishinaka A, Hirose J, Asaoka Y, Tajiri M, Hayata A, Ishida S, Omoto S, Nagira M, Ishii KJ. A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via alpha-tocopherol component. Front Immunol. 14:1116238. https://doi.org/10.3389/fimmu.2023.1116238 (2023)

114. Best K, Ikeuchi K, Kater L, Best D, Musial J, Matsuo Y, Berninghausen O, Becker T, Inada T, Beckmann R. Structural basis for clearing of ribosome collisions by the RQT complex. Nat Commun. 14(1):921-8. https://doi.org/10.1038/s41467-023-36230-8 (2023)

論文解説　異常翻訳の実体である衝突リボソームの解消機構 ――mRNA引っ張り力によるリボソーム構造変化による異常翻訳解消機構――

115. Tesina P, Ebine S, Buschauer R, Thoms M, Matsuo Y, Inada T, Beckmann R. Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol Cell. 83(4):607-621.e4. https://doi.org/10.1016/j.molcel.2023.01.020 (2023)

論文解説　非典型翻訳反応における翻訳因子eIF5Aの機能の解明 ――mRNAを必要とせずにペプチド合成反応を行う仕組み――

116. Soga T, Duong C, Pattinson D, Sakai-Tagawa Y, Tokita A, Izumida N, Nishino T, Hagiwara H, Wada N, Miyamoto Y, Kuroki H, Hayashi Y, Seki M, Kasuya N, Koga M, Adachi E, Iwatsuki-Horimoto K, Yotsuyanagi H, Yamayoshi S, Kawaoka Y. Characterization of Influenza A(H1N1)pdm09 Viruses Isolated in the 2018-2019 and 2019-2020 Influenza Seasons in Japan. Viruses. 15(2):535. https://doi.org/10.3390/v15020535 (2023)

117. Mahita J, Ha B, Gambiez A, Schendel SL, Li H, Hastie KM, Dennison SM, Li K, Kuzmina N, Periasamy S, Bukreyev A, Munt JE, Osei-Twum M, Atyeo C, Overton JA, Vita R, Guzman-Orozco H, Mendes M, Kojima M, Halfmann PJ, Kawaoka Y, Alter G, Gagnon L, Baric RS, Tomaras GD, Germann T, Bedinger D, Greenbaum JA, Saphire EO, Peters B. Coronavirus Immunotherapeutic Consortium Database. Database (Oxford). 2023:10.1093/database/baac112. https://doi.org/10.1093/database/baac112 (2023)

118. Miyashita R, Nishiyama A, Qin W, Chiba Y, Kori S, Kato N, Konishi C, Kumamoto S, Kozuka-Hata H, Oyama M, Kawasoe Y, Tsurimoto T, Takahashi TS, Leonhardt H, Arita K, Nakanishi M. The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Elife. 12:10.7554/eLife.79013. https://doi.org/10.7554/eLife.79013 (2023)

119. Chen S, Quan DH, Sam G, Ozberk V, Wang XT, Halfmann P, Pandey M, Good MF, Kawaoka Y, Britton WJ, Rehm BHA. Assembly of Immunogenic Protein Particles toward Advanced Synthetic Vaccines. Small. 19(8):e2205819. https://doi.org/10.1002/smll.202205819 (2023)

120. Sugimori Y, Iwasaki Y, Takeshima Y, Okubo M, Kobayashi S, Hatano H, Yamada S, Nakano M, Yoshida R, Ota M, Tsuchida Y, Nagafuchi Y, Shimane K, Yoshida K, Kurosaka D, Sumitomo S, Shoda H, Yamamoto K, Okamura T, Fujio K. Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of Myositis-Specific Antibody-Positive Inflammatory Myopathies. ACR Open Rheumatol. 5(2):93-102. https://doi.org/10.1002/acr2.11521 (2023)

121. Neumann G, Kawaoka Y. The COVID-19 Pandemic-A Potential Role for Antivirals in Mitigating Pandemics. Viruses. 15(2):303. https://doi.org/10.3390/v15020303 (2023)

122. Braun KM, Haddock Iii LA, Crooks CM, Barry GL, Lalli J, Neumann G, Watanabe T, Imai M, Yamayoshi S, Ito M, Moncla LH, Koelle K, Kawaoka Y, Friedrich TC. Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals. Virus Evol. 9(1):vead004. https://doi.org/10.1093/ve/vead004 (2023)

123. Ly MHP, Nguyen CT, Nguyen TV, Nguyen TTN, Nabeshima T, Adungo F, Takamatsu Y, Huy NT, Le TQM, Morita K, Hasebe F, Moi ML. Differential Infectivity of Human Neural Cell Lines by a Dengue Virus Serotype-3 Genotype-III with a Distinct Nonstructural Protein 2A (NS2A) Amino Acid Substitution Isolated from the Cerebrospinal Fluid of a Dengue Encephalitis Patient. Can J Infect Dis Med Microbiol. 2023:2635383. https://doi.org/10.1155/2023/2635383 (2023)

124. Muro R, Narita T, Nitta T, Takayanagi H. Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation. Front Immunol. 13:1045881. https://doi.org/10.3389/fimmu.2022.1045881 (2023)

125. Moritoyo T, Nishimura N, Hasegawa K, Ishii S, Kirihara K, Takata M, Svensson AK, Umeda-Kameyama Y, Kawarasaki S, Ihara R, Sakanaka C, Wakabayashi Y, Niizuma K, Tominaga T, Yamazaki T, Hasumi K. A first-in-human study of the anti-inflammatory profibrinolytic TMS-007, an SMTP family triprenyl phenol. Br J Clin Pharmacol. https://doi.org/10.1111/bcp.15651 (2023)

126. Tomomatsu S, Watanabe A, Tesina P, Hashimoto S, Ikeuchi K, Li S, Matsuo Y, Beckmann R, Inada T. Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay. Nucleic Acids Res. 51(1):253-270. https://doi.org/10.1093/nar/gkac1172 (2023)

論文解説　リボソーム衝突に依存したmRNAの内部切断の仕組み

127. Matsuo Y, Uchihashi T, Inada T. Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex. Nat Commun. 14(1):79-4. https://doi.org/10.1038/s41467-022-35608-4 (2023)

論文解説　リボソームの異常な交通渋滞を選別するしくみを解明 ――高速AFMを用いて品質管理を司る複合体の動きを可視化――

128. Minagawa Y, Nakata S, Date M, Ii Y, Noji H. On-Chip Enrichment System for Digital Bioassay Based on Aqueous Two-Phase System. ACS Nano. 17(1):212-220. https://doi.org/10.1021/acsnano.2c06007 (2023)

129. Neumann G, Kawaoka Y. Which Virus Will Cause the Next Pandemic? Viruses. 15(1):199. https://doi.org/10.3390/v15010199 (2023)

130. Chiba S, Hatta M, Pattinson D, Yasuhara A, Neumann G, Kawaoka Y. Ferret model to mimic the sequential exposure of humans to historical H3N2 influenza viruses. Vaccine. 41(2):590-597. https://doi.org/10.1016/j.vaccine.2022.12.005 (2023)

131. Imai M, Ito M, Kiso M, Yamayoshi S, Uraki R, Fukushi S, Watanabe S, Suzuki T, Maeda K, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Halfmann PJ, Kawaoka Y. Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB. N Engl J Med. 388(1):89-91. https://doi.org/10.1056/NEJMc2214302 (2023)

論文解説　臨床検体から分離した新型コロナウイルス・オミクロン株の BQ.1.1系統とXBB系統に対する治療薬の効果を検証

132. Jin J, Ogawa T, Hojo N, Kryukov K, Shimizu K, Ikawa T, Imanishi T, Okazaki T, Shiroguchi K. Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes. Proc Natl Acad Sci U S A. 120(1):e2210283120. https://doi.org/10.1073/pnas.2210283120 (2023)

133. Takashita E, Watanabe S, Hasegawa H, Kawaoka Y. Are twindemics occurring? Influenza Other Respir Viruses. 17(1):e13090. https://doi.org/10.1111/irv.13090 (2023)

論文解説　新型コロナウイルス感染症とインフルエンザが同時流行しているかを検証

134. Bae C, Katoh H, Wakata A, Sakata M, Kato F, Takeda M. Demonstration of bacterium-free very rapid reverse genetics system using mumps virus. Microbiol Immunol. 67(1):44-47. https://doi.org/10.1111/1348-0421.13032 (2023)

135. Koga M, Iwatsuki-Horimoto K, Kikuchi T, Yamayoshi S, Kawaoka Y, Yotsuyanagi H. Previous omicron infection may be protective against reinfection with omicron variant BA.5 for at least 5 months. Clin Microbiol Infect. 29(1):120-121. https://doi.org/10.1016/j.cmi.2022.09.009 (2023)

136. Uraki R, Ito M, Furusawa Y, Yamayoshi S, Iwatsuki-Horimoto K, Adachi E, Saito M, Koga M, Tsutsumi T, Yamamoto S, Otani A, Kiso M, Sakai-Tagawa Y, Ueki H, Yotsuyanagi H, Imai M, Kawaoka Y. Humoral immune evasion of the omicron subvariants BQ.1.1 and XBB. Lancet Infect Dis. 23(1):30-32. https://doi.org/10.1016/S1473-3099(22)00816-7 (2023)

論文解説　ワクチン被接種者あるいはブレイクスルー感染者血漿の、 臨床検体から分離した新型コロナウイルス・オミクロン株の BQ.1.1系統とXBB系統に対する反応性を検証

137. Furuya G, Katoh H, Atsumi S, Hashimoto I, Komura D, Hatanaka R, Senga S, Hayashi S, Akita S, Matsumura H, Miura A, Mita H, Nakakido M, Nagatoishi S, Sugiyama A, Suzuki R, Konishi H, Yamamoto A, Abe H, Hiraoka N, Aoki K, Kato Y, Seto Y, Yoshimura C, Miyadera K, Tsumoto K, Ushiku T, Ishikawa S. Nucleic acid-triggered tumoral immunity propagates pH-selective therapeutic antibodies through tumor-driven epitope spreading. Cancer Sci. 114(1):321-338. https://doi.org/10.1111/cas.15596 (2023)

138. Atsumi Y, Toriyama M, Kato H, Nakamura M, Morita A, Takaishi M, Saito K, Tanaka M, Okada F, Tominaga M, Ishii KJ, Fujita F. Anti-Inflammatory Role of TRPV4 in Human Macrophages. Immunohorizons. 7(1):81-96. https://doi.org/10.4049/immunohorizons.2200100 (2023) 

139. 塚崎 雅之, 高柳 広. 【最新の骨粗鬆症学(第2版)-骨粗鬆症学の最新知見-】骨研究フロンティア　骨代謝を調節する微細環境　免疫系. 日臨. 81(増刊1 最新の骨粗鬆症学):111-117. (2023) 

140. 鶴町 真也, 平野 利忠, 山田 泰広. 生体内リプログラミングによる膵島細胞の増殖誘導. 医学のあゆみ. 284(11):885-889. (2023) https://cir.nii.ac.jp/crid/1520577215748432768

2022

1. Eiden J, Fierro C, Schwartz H, Adams M, Ellis KJ, Aitchison R, Herber R, Hatta Y, Marshall D, Moser MJ, Belshe R, Greenberg H, Coelingh K, Kawaoka Y, Neumann G, Bilsel P. Intranasal M2SR (M2-Deficient Single Replication) H3N2 Influenza Vaccine Provides Enhanced Mucosal and Serum Antibodies in Adults. J Infect Dis. 227(1):103-112. https://doi.org/10.1093/infdis/jiac433 (2022)

2. Takeshita M, Fukuyama H, Kamada K, Matsumoto T, Makino-Okamura C, Uchikubo-Kamo T, Tomabechi Y, Hanada K, Moriyama S, Takahashi Y, Ishigaki H, Nakayama M, Nguyen CT, Kitagawa Y, Itoh Y, Imai M, Maemura T, Furusawa Y, Ueki H, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Kawaoka Y, Shirouzu M, Ishii M, Saya H, Kondo Y, Kaneko Y, Suzuki K, Fukunaga K, Takeuchi T. Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models. iScience. 25(12):105596. https://doi.org/10.1016/j.isci.2022.105596 (2022)

3. Takeshima K, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y. Redundant and Specific Roles of A-Type Lamins and Lamin B Receptor in Herpes Simplex Virus 1 Infection. J Virol. 96(24):1429. https://doi.org/10.1128/jvi.01429-22 (2022)

4. Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada H, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat Commun. 13(1):7857-0. https://doi.org/10.1038/s41467-022-35501-0 (2022)

5. Kawasaki T, Ikegawa M, Yunoki K, Otani H, Ori D, Ishii KJ, Kuroda E, Takamura S, Kitabatake M, Ito T, Isotani A, Kawai T. Alveolar macrophages instruct CD8(+) T cell expansion by antigen cross-presentation in lung. Cell Rep. 41(11):111828. https://doi.org/10.1016/j.celrep.2022.111828 (2022)

6. Sarawar S, Gabaglia CR, Sanchez A, Hatta Y, Dias P, Neumann G, Kawaoka Y, Bilsel P. Longevity and Mechanism of Heterosubtypic Protection Induced by M2SR (M2-Deficient Single-Replication) Live Influenza Virus Vaccine in Mice. Vaccines (Basel). 10(12):2131. doi: 10.3390/vaccines10122131. https://doi.org/10.3390/vaccines10122131 (2022)

7. Ohe S, Kubota Y, Yamaguchi K, Takagi Y, Nashimoto J, Kozuka-Hata H, Oyama M, Furukawa Y, Takekawa M. ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II. Nat Commun. 13(1):7476-4. https://doi.org/10.1038/s41467-022-35230-4 (2022)

論文解説　細胞増殖と発癌を司る初期応答遺伝子群の新たな発現調節機構の解明 ―増殖シグナルがRNAポリメラーゼIIの転写伸長反応を制御する仕組みを発見―

8. Boon ACM, Darling TL, Halfmann PJ, Franks J, Webby RJ, Barouch DH, Port JR, Munster VJ, Diamond MS, Kawaoka Y. Reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters. PLoS Pathog. 18(12):e1010970. https://doi.org/10.1371/journal.ppat.1010970 (2022)

9. Uraki R, Halfmann PJ, Iida S, Yamayoshi S, Furusawa Y, Kiso M, Ito M, Iwatsuki-Horimoto K, Mine S, Kuroda M, Maemura T, Sakai-Tagawa Y, Ueki H, Li R, Liu Y, Larson D, Fukushi S, Watanabe S, Maeda K, Pekosz A, Kandeil A, Webby RJ, Wang Z, Imai M, Suzuki T, Kawaoka Y. Characterization of SARS-CoV-2 Omicron BA.4 and BA.5 isolates in rodents. Nature. 612(7940):540-545. https://doi.org/10.1038/s41586-022-05482-7 (2022)

論文解説　患者から分離した新型コロナウイルス・オミクロン変異株のBA.4系統ならびにBA.5系統の性状解明

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論文解説　哺乳類においてリボソームの衝突に対処する仕組み ――ユビキチン修飾を介した翻訳停滞の解消を試験管内で再現――

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